Polymorphous Light Eruption Clinic Aspects and Pathogenesis

被引：58

作者：

Gruber-Wackernagel, Alexandra ^{[1
]}

Byrne, Scott N. ^{[2
]}

Wolf, Peter ^{[1
]}

机构：

[1] Med Univ Graz, Dept Dermatol, Res Unit Photodermatol, A-8036 Graz, Austria

[2] Univ Sydney, Royal Prince Alfred Hosp, Sydney Med Sch, Dept Dermatol, Darlington, NSW 2006, Australia

来源：

DERMATOLOGIC CLINICS | 2014年 / 32卷 / 03期

基金：

奥地利科学基金会;

关键词：

Polymorphous light eruption; Polymorphic; Photoantigen; Immune suppression; Cytokines; Chemotaxis; Photoprotection; Skin cancer; TUMOR-NECROSIS-FACTOR; LANGERHANS CELL-MIGRATION; CONTACT HYPERSENSITIVITY RESPONSES; VITAMIN-D STATUS; CUTANEOUS LUPUS-ERYTHEMATOSUS; PLASMACYTOID DENDRITIC CELLS; PLATELET-ACTIVATING-FACTOR; INDUCED IMMUNE SUPPRESSION; JUVENILE SPRING ERUPTION; ANTIGEN-PRESENTING CELLS;

D O I：

10.1016/j.det.2014.03.012

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Polymorphous light eruption is an immunologically mediated photodermatosis with high prevalence, particularly among young women in temperate climates, characterized by pruritic skin lesions of variable morphology, occurring in spring or early summer on sun-exposed body sites. A resistance to ultraviolet radiation (UVR)-induced immunosuppression and a subsequent delayed-type hypersensitivity response to a photoantigen have been suggested as key factors in the disease. Molecular and immunologic disturbances associated with disease pathogenesis include a failure of skin infiltration by neutrophils and other regulatory immune cells on UVR exposure linked to a disturbed cytokine microenvironment. Standard management is based on prevention.

引用

页码：315 / +

页数：21

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