Non-steroidal pregnancy-terminating agents:: Design, synthesis and structure-activity relationships of 2-aryl-1,2,4-triazolo[1,5-a]pyridine

被引:11
作者
Liu, T [1 ]
Hu, YZ [1 ]
机构
[1] Zhejiang Univ, Coll Pharm, Dept Med Chem, Hangzhou 310031, Peoples R China
关键词
D O I
10.1016/S0960-894X(02)00399-2
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
The syntheses and the pregnancy-terminating activity relationships of compounds 5a-n are reported. Compounds 5b and 5l are found to be more potent than DL-111-a known drug having effective pregnancy-terminating activity in vitro. Further research shows compounds 5b and 5l have the same activity as DL-111 in vivo. We also found an exciting result that they have excellent anti-implantation activity after oral administration. (C) 2002 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:2411 / 2413
页数:3
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