Prevalence of autoantibodies against structure specific recognition protein 1 in systemic lupus erythematosus

被引:4
作者
Fineschi, S
Borghi, MO
Riboldi, P
Gariglio, M
Buzio, C
Landolfo, S
Cebecauer, L
Tuchynova, A
Rovensky, J
Meroni, PL
机构
[1] Ist Auxol Italiano, IRCCS, Allergy Clin Immunol & Rheumatol Unit, I-20145 Milan, Italy
[2] Univ Milan, Dept Internal Med, Milan, Italy
[3] Univ Eastern Peidmont, Dept Med Sci, Novara, Italy
[4] Univ Parma, Dept Clin Med Nephrol & Hlth Sci, I-43100 Parma, Italy
[5] Univ Turin, Dept Publ Hlth & Microbiol, Turin, Italy
[6] Natl Inst Rheumat Dis, Piestany, Slovakia
关键词
autoantibodies; SSRP1; systemic lupus erythematosus;
D O I
10.1191/0961203304lu1049oa
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Antibodies (Abs) against the structure specific recognition protein 1 (SSRP1) were reported in a small systemic lupus erythematosus (SLE) series but not in other systemic autoimmune diseases. The aim of the study was to confirm the selective presence of anti-SSRP1 Abs in a larger SLE series and to evaluate their relationship with disease activity and other immune markers. Anti-SSRP1 Abs were investigated by a 'home made' ELISA in: 120 SLE, 65 rheumatoid arthritis ( RA), 51 systemic sclerosis (SSc), 23 Churg-Strauss syndrome (CSS) and 40 idiopathic autoimmune urticaria (IAU) patients and 190 healthy controls. Sera from MRL lpr/lpr and Balb-c mice were also tested. Anti-SSRP1 Abs were detected in 43 SLE (35.8%), nine SSc (17.6%), eight RA (12.3%), six IAU (15%), three CSS (13%) patients and five healthy controls (2.6%). Antibody prevalence and titers were significantly higher in SLE patients than in sera from both normal and disease controls. Anti-SSRP1 Ab activity was also detected in sera from MRL lpr/lpr but not Balb-c mice. The antibodies did not correlate with the disease activity evaluated as the ECLAM index score and were more prevalent in patients without renal involvement. No correlation was found with other serum autoantibodies. Our results confirm that anti-SSRP1 Abs are associated with but not specific for the lupus disease.
引用
收藏
页码:463 / 468
页数:6
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