Dramatic increases in hippocampal spine synapse density are known to occur within minutes of estrogen exposure. Until now, it has been assumed that enhanced spinogenesis increased excitatory input received by the CA1 pyramidal neurons, but how this facilitated learning and memory was unclear. Delivery of 17a-estradiol or an estrogen receptor (ER)-alpha (but not ER-beta) agonist into the dorsal hippocampus rapidly improved general discrimination learning in female mice. The same treatments increased CA1 dendritic spines in hippocampal sections over a time course consistent with the learning acquisition phase. Surprisingly, estrogen-activated spinogenesis was associated with a decrease in CA1 hippocampal excitatory input, rapidly and transiently reducing CA1 AMPA activity via a mechanism likely reflecting AMPA receptor internalization and creation of silent or immature synapses. We propose that estrogens promote hippocampally mediated learning via a mechanism resembling some of the broad features of normal development, an initial overproduction of functionally immature connections being subsequently pruned by experience.
机构:
Stanford Univ, James H Clark Ctr Biomed Engn & Sci, Stanford, CA 94305 USA
Stanford Univ, Howard Hughes Med Inst, Stanford, CA 94305 USAStanford Univ, James H Clark Ctr Biomed Engn & Sci, Stanford, CA 94305 USA
Attardo, Alessio
Fitzgerald, James E.
论文数: 0引用数: 0
h-index: 0
机构:
Stanford Univ, James H Clark Ctr Biomed Engn & Sci, Stanford, CA 94305 USAStanford Univ, James H Clark Ctr Biomed Engn & Sci, Stanford, CA 94305 USA
机构:
Western Univ Hlth Sci, Grad Coll Biomed Sci, Pomona, CA 91766 USA
Katholieke Univ Leuven, VIB Ctr Biol Dis, B-3000 Leuven, BelgiumWestern Univ Hlth Sci, Grad Coll Biomed Sci, Pomona, CA 91766 USA
Briz, Victor
Liu, Yan
论文数: 0引用数: 0
h-index: 0
机构:
Western Univ Hlth Sci, Grad Coll Biomed Sci, Pomona, CA 91766 USA
Western Univ Hlth Sci, Coll Osteopath Med Pacific, Pomona, CA 91766 USAWestern Univ Hlth Sci, Grad Coll Biomed Sci, Pomona, CA 91766 USA
Liu, Yan
Zhu, Guoqi
论文数: 0引用数: 0
h-index: 0
机构:
Western Univ Hlth Sci, Grad Coll Biomed Sci, Pomona, CA 91766 USA
Anhui Univ Tradit Chinese Med, Minist Educ, Key Lab Xinan Med, Hefei 230038, Peoples R ChinaWestern Univ Hlth Sci, Grad Coll Biomed Sci, Pomona, CA 91766 USA
Zhu, Guoqi
Bi, Xiaoning
论文数: 0引用数: 0
h-index: 0
机构:
Western Univ Hlth Sci, Coll Osteopath Med Pacific, Pomona, CA 91766 USAWestern Univ Hlth Sci, Grad Coll Biomed Sci, Pomona, CA 91766 USA
Bi, Xiaoning
Baudry, Michel
论文数: 0引用数: 0
h-index: 0
机构:
Western Univ Hlth Sci, Grad Coll Biomed Sci, Pomona, CA 91766 USAWestern Univ Hlth Sci, Grad Coll Biomed Sci, Pomona, CA 91766 USA
机构:
Chongqing Med Univ, Childrens Hosp, Key Lab Child Dev & Disorders, Minist Educ, Chongqing 400014, Peoples R China
Chongqing Med Univ, Childrens Hosp, Chongqing Key Lab Translat Med Res Cognit Dev & L, Chongqing 400014, Peoples R ChinaUniv British Columbia, Brain Res Ctr, Vancouver, BC V6T 2B5, Canada
Dong, Zhifang
Bai, Yanrui
论文数: 0引用数: 0
h-index: 0
机构:
Chongqing Med Univ, Childrens Hosp, Key Lab Child Dev & Disorders, Minist Educ, Chongqing 400014, Peoples R China
Chongqing Med Univ, Childrens Hosp, Chongqing Key Lab Translat Med Res Cognit Dev & L, Chongqing 400014, Peoples R ChinaUniv British Columbia, Brain Res Ctr, Vancouver, BC V6T 2B5, Canada
Bai, Yanrui
Wu, Xiaoyan
论文数: 0引用数: 0
h-index: 0
机构:
Chongqing Med Univ, Childrens Hosp, Key Lab Child Dev & Disorders, Minist Educ, Chongqing 400014, Peoples R China
Chongqing Med Univ, Childrens Hosp, Chongqing Key Lab Translat Med Res Cognit Dev & L, Chongqing 400014, Peoples R ChinaUniv British Columbia, Brain Res Ctr, Vancouver, BC V6T 2B5, Canada
Wu, Xiaoyan
Li, Hongjie
论文数: 0引用数: 0
h-index: 0
机构:
Chongqing Med Univ, Childrens Hosp, Key Lab Child Dev & Disorders, Minist Educ, Chongqing 400014, Peoples R China
Chongqing Med Univ, Childrens Hosp, Chongqing Key Lab Translat Med Res Cognit Dev & L, Chongqing 400014, Peoples R ChinaUniv British Columbia, Brain Res Ctr, Vancouver, BC V6T 2B5, Canada
Li, Hongjie
Gong, Bo
论文数: 0引用数: 0
h-index: 0
机构:
Univ British Columbia, Brain Res Ctr, Vancouver, BC V6T 2B5, CanadaUniv British Columbia, Brain Res Ctr, Vancouver, BC V6T 2B5, Canada
Gong, Bo
Howland, John G.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Saskatchewan, Dept Physiol, Neural Syst & Plast Res Grp, Saskatoon, SK S7N 3R2, CanadaUniv British Columbia, Brain Res Ctr, Vancouver, BC V6T 2B5, Canada
Howland, John G.
Huang, Yan
论文数: 0引用数: 0
h-index: 0
机构:
Chongqing Med Univ, Childrens Hosp, Key Lab Child Dev & Disorders, Minist Educ, Chongqing 400014, Peoples R China
Chongqing Med Univ, Childrens Hosp, Chongqing Key Lab Translat Med Res Cognit Dev & L, Chongqing 400014, Peoples R ChinaUniv British Columbia, Brain Res Ctr, Vancouver, BC V6T 2B5, Canada
Huang, Yan
He, Wenting
论文数: 0引用数: 0
h-index: 0
机构:
Chongqing Med Univ, Childrens Hosp, Key Lab Child Dev & Disorders, Minist Educ, Chongqing 400014, Peoples R China
Chongqing Med Univ, Childrens Hosp, Chongqing Key Lab Translat Med Res Cognit Dev & L, Chongqing 400014, Peoples R ChinaUniv British Columbia, Brain Res Ctr, Vancouver, BC V6T 2B5, Canada
He, Wenting
Li, Tingyu
论文数: 0引用数: 0
h-index: 0
机构:
Chongqing Med Univ, Childrens Hosp, Key Lab Child Dev & Disorders, Minist Educ, Chongqing 400014, Peoples R China
Chongqing Med Univ, Childrens Hosp, Chongqing Key Lab Translat Med Res Cognit Dev & L, Chongqing 400014, Peoples R ChinaUniv British Columbia, Brain Res Ctr, Vancouver, BC V6T 2B5, Canada
Li, Tingyu
Wang, Yu Tian
论文数: 0引用数: 0
h-index: 0
机构:
Univ British Columbia, Brain Res Ctr, Vancouver, BC V6T 2B5, Canada
Chongqing Med Univ, Childrens Hosp, Key Lab Child Dev & Disorders, Minist Educ, Chongqing 400014, Peoples R China
Chongqing Med Univ, Childrens Hosp, Chongqing Key Lab Translat Med Res Cognit Dev & L, Chongqing 400014, Peoples R ChinaUniv British Columbia, Brain Res Ctr, Vancouver, BC V6T 2B5, Canada
机构:
Nathan S Kline Inst Psychiat Res, Ctr Dementia Res, Orangeburg, NY 10962 USA
NYU, Langone Med Ctr, Dept Child & Adolescent Psychiat, New York, NY 10016 USANathan S Kline Inst Psychiat Res, Ctr Dementia Res, Orangeburg, NY 10962 USA
Harte-Hargrove, L. C.
Maclusky, N. J.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Guelph, Dept Biomed Sci, Guelph, ON N1G 2W1, CanadaNathan S Kline Inst Psychiat Res, Ctr Dementia Res, Orangeburg, NY 10962 USA
Maclusky, N. J.
Scharfman, H. E.
论文数: 0引用数: 0
h-index: 0
机构:
Nathan S Kline Inst Psychiat Res, Ctr Dementia Res, Orangeburg, NY 10962 USA
NYU, Langone Med Ctr, Dept Child & Adolescent Psychiat, New York, NY 10016 USA
NYU, Langone Med Ctr, Dept Physiol, New York, NY 10016 USA
NYU, Langone Med Ctr, Dept Neurosci, New York, NY 10016 USANathan S Kline Inst Psychiat Res, Ctr Dementia Res, Orangeburg, NY 10962 USA
机构:
Stanford Univ, James H Clark Ctr Biomed Engn & Sci, Stanford, CA 94305 USA
Stanford Univ, Howard Hughes Med Inst, Stanford, CA 94305 USAStanford Univ, James H Clark Ctr Biomed Engn & Sci, Stanford, CA 94305 USA
Attardo, Alessio
Fitzgerald, James E.
论文数: 0引用数: 0
h-index: 0
机构:
Stanford Univ, James H Clark Ctr Biomed Engn & Sci, Stanford, CA 94305 USAStanford Univ, James H Clark Ctr Biomed Engn & Sci, Stanford, CA 94305 USA
机构:
Western Univ Hlth Sci, Grad Coll Biomed Sci, Pomona, CA 91766 USA
Katholieke Univ Leuven, VIB Ctr Biol Dis, B-3000 Leuven, BelgiumWestern Univ Hlth Sci, Grad Coll Biomed Sci, Pomona, CA 91766 USA
Briz, Victor
Liu, Yan
论文数: 0引用数: 0
h-index: 0
机构:
Western Univ Hlth Sci, Grad Coll Biomed Sci, Pomona, CA 91766 USA
Western Univ Hlth Sci, Coll Osteopath Med Pacific, Pomona, CA 91766 USAWestern Univ Hlth Sci, Grad Coll Biomed Sci, Pomona, CA 91766 USA
Liu, Yan
Zhu, Guoqi
论文数: 0引用数: 0
h-index: 0
机构:
Western Univ Hlth Sci, Grad Coll Biomed Sci, Pomona, CA 91766 USA
Anhui Univ Tradit Chinese Med, Minist Educ, Key Lab Xinan Med, Hefei 230038, Peoples R ChinaWestern Univ Hlth Sci, Grad Coll Biomed Sci, Pomona, CA 91766 USA
Zhu, Guoqi
Bi, Xiaoning
论文数: 0引用数: 0
h-index: 0
机构:
Western Univ Hlth Sci, Coll Osteopath Med Pacific, Pomona, CA 91766 USAWestern Univ Hlth Sci, Grad Coll Biomed Sci, Pomona, CA 91766 USA
Bi, Xiaoning
Baudry, Michel
论文数: 0引用数: 0
h-index: 0
机构:
Western Univ Hlth Sci, Grad Coll Biomed Sci, Pomona, CA 91766 USAWestern Univ Hlth Sci, Grad Coll Biomed Sci, Pomona, CA 91766 USA
机构:
Chongqing Med Univ, Childrens Hosp, Key Lab Child Dev & Disorders, Minist Educ, Chongqing 400014, Peoples R China
Chongqing Med Univ, Childrens Hosp, Chongqing Key Lab Translat Med Res Cognit Dev & L, Chongqing 400014, Peoples R ChinaUniv British Columbia, Brain Res Ctr, Vancouver, BC V6T 2B5, Canada
Dong, Zhifang
Bai, Yanrui
论文数: 0引用数: 0
h-index: 0
机构:
Chongqing Med Univ, Childrens Hosp, Key Lab Child Dev & Disorders, Minist Educ, Chongqing 400014, Peoples R China
Chongqing Med Univ, Childrens Hosp, Chongqing Key Lab Translat Med Res Cognit Dev & L, Chongqing 400014, Peoples R ChinaUniv British Columbia, Brain Res Ctr, Vancouver, BC V6T 2B5, Canada
Bai, Yanrui
Wu, Xiaoyan
论文数: 0引用数: 0
h-index: 0
机构:
Chongqing Med Univ, Childrens Hosp, Key Lab Child Dev & Disorders, Minist Educ, Chongqing 400014, Peoples R China
Chongqing Med Univ, Childrens Hosp, Chongqing Key Lab Translat Med Res Cognit Dev & L, Chongqing 400014, Peoples R ChinaUniv British Columbia, Brain Res Ctr, Vancouver, BC V6T 2B5, Canada
Wu, Xiaoyan
Li, Hongjie
论文数: 0引用数: 0
h-index: 0
机构:
Chongqing Med Univ, Childrens Hosp, Key Lab Child Dev & Disorders, Minist Educ, Chongqing 400014, Peoples R China
Chongqing Med Univ, Childrens Hosp, Chongqing Key Lab Translat Med Res Cognit Dev & L, Chongqing 400014, Peoples R ChinaUniv British Columbia, Brain Res Ctr, Vancouver, BC V6T 2B5, Canada
Li, Hongjie
Gong, Bo
论文数: 0引用数: 0
h-index: 0
机构:
Univ British Columbia, Brain Res Ctr, Vancouver, BC V6T 2B5, CanadaUniv British Columbia, Brain Res Ctr, Vancouver, BC V6T 2B5, Canada
Gong, Bo
Howland, John G.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Saskatchewan, Dept Physiol, Neural Syst & Plast Res Grp, Saskatoon, SK S7N 3R2, CanadaUniv British Columbia, Brain Res Ctr, Vancouver, BC V6T 2B5, Canada
Howland, John G.
Huang, Yan
论文数: 0引用数: 0
h-index: 0
机构:
Chongqing Med Univ, Childrens Hosp, Key Lab Child Dev & Disorders, Minist Educ, Chongqing 400014, Peoples R China
Chongqing Med Univ, Childrens Hosp, Chongqing Key Lab Translat Med Res Cognit Dev & L, Chongqing 400014, Peoples R ChinaUniv British Columbia, Brain Res Ctr, Vancouver, BC V6T 2B5, Canada
Huang, Yan
He, Wenting
论文数: 0引用数: 0
h-index: 0
机构:
Chongqing Med Univ, Childrens Hosp, Key Lab Child Dev & Disorders, Minist Educ, Chongqing 400014, Peoples R China
Chongqing Med Univ, Childrens Hosp, Chongqing Key Lab Translat Med Res Cognit Dev & L, Chongqing 400014, Peoples R ChinaUniv British Columbia, Brain Res Ctr, Vancouver, BC V6T 2B5, Canada
He, Wenting
Li, Tingyu
论文数: 0引用数: 0
h-index: 0
机构:
Chongqing Med Univ, Childrens Hosp, Key Lab Child Dev & Disorders, Minist Educ, Chongqing 400014, Peoples R China
Chongqing Med Univ, Childrens Hosp, Chongqing Key Lab Translat Med Res Cognit Dev & L, Chongqing 400014, Peoples R ChinaUniv British Columbia, Brain Res Ctr, Vancouver, BC V6T 2B5, Canada
Li, Tingyu
Wang, Yu Tian
论文数: 0引用数: 0
h-index: 0
机构:
Univ British Columbia, Brain Res Ctr, Vancouver, BC V6T 2B5, Canada
Chongqing Med Univ, Childrens Hosp, Key Lab Child Dev & Disorders, Minist Educ, Chongqing 400014, Peoples R China
Chongqing Med Univ, Childrens Hosp, Chongqing Key Lab Translat Med Res Cognit Dev & L, Chongqing 400014, Peoples R ChinaUniv British Columbia, Brain Res Ctr, Vancouver, BC V6T 2B5, Canada
机构:
Nathan S Kline Inst Psychiat Res, Ctr Dementia Res, Orangeburg, NY 10962 USA
NYU, Langone Med Ctr, Dept Child & Adolescent Psychiat, New York, NY 10016 USANathan S Kline Inst Psychiat Res, Ctr Dementia Res, Orangeburg, NY 10962 USA
Harte-Hargrove, L. C.
Maclusky, N. J.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Guelph, Dept Biomed Sci, Guelph, ON N1G 2W1, CanadaNathan S Kline Inst Psychiat Res, Ctr Dementia Res, Orangeburg, NY 10962 USA
Maclusky, N. J.
Scharfman, H. E.
论文数: 0引用数: 0
h-index: 0
机构:
Nathan S Kline Inst Psychiat Res, Ctr Dementia Res, Orangeburg, NY 10962 USA
NYU, Langone Med Ctr, Dept Child & Adolescent Psychiat, New York, NY 10016 USA
NYU, Langone Med Ctr, Dept Physiol, New York, NY 10016 USA
NYU, Langone Med Ctr, Dept Neurosci, New York, NY 10016 USANathan S Kline Inst Psychiat Res, Ctr Dementia Res, Orangeburg, NY 10962 USA