Overexpression of c-met in the early stage of pancreatic carcinogenesis;: altered expression is not sufficient for progression from chronic pancreatitis to pancreatic cancer

被引:36
作者
Yu, Jun [1 ]
Ohuchida, Kenoki [1 ]
Mizumoto, Kazuhiro [1 ]
Ishikawa, Nami [1 ]
Ogura, Yasuhiro [1 ]
Yamada, Daisuke [1 ]
Egami, Takuya [1 ]
Fujita, Hayato [1 ]
Ohashi, Seiji [1 ]
Nagai, Eishi [1 ]
Tanaka, Masao [1 ]
机构
[1] Kyushu Univ, Grad Sch Med Sci, Dept Surg & Oncol, Fukuoka 8128582, Japan
关键词
c-met; pancreatic cancer; chronic pancreatitis; pancreatic carcinogenesis;
D O I
10.3748/wjg.v12.i24.3878
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
AIM: To investigate c-met expression during early pancreatic carcinogenesis. METHODS: We used 46 bulk tissues and 36 micro-dissected samples, including normal pancreas, chronic pancreatitis, and pancreatic cancer, for quantitative real-time reverse transcription-polymerase chain reaction. RESULTS: In bulk tissue analyses, pancreatic cancer tissues expressed significantly higher levels of c-met than did chronic pancreatitis and normal pancreas tissues. c-met levels did not differ between chronic pancreatitis and normal pancreas tissues. In microdissection-based analyses, c-met was expressed at higher levels in microdissected pancreatic cancer cells and pancreatitis-affected epithelial cells than in normal ductal epithelial cells (both, P < 0.01). Interestingly, pancreatitis-affected epithelial cells expressed levels of c-met similar to those of pancreatic cancer cells. CONCLUSION: Overexpression of c-met occurs during the early stage of pancreatic carcinogenesis, and a single alteration of c-met expression is not sufficient for progression of chronic pancreatitis-affected epithelial cells to pancreatic cancer cells. (C) 2006 The WJG Press. All rights reserved.
引用
收藏
页码:3878 / 3882
页数:5
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