Addressing the Immunopathogenesis of Atopic Dermatitis: Advances in Topical and Systemic Treatment

被引：10

作者：

Eichenfield, Lawrence F. ^{[1
,2
]}

Gold, Linda F. Stein ^{[3
]}

机构：

[1] Univ Calif San Diego, San Diego Sch Med, Rady Childrens Hosp, Pediat & Adolescent Dermatol, San Diego, CA 92103 USA

[2] Univ Calif San Diego, San Diego Sch Med, Rady Childrens Hosp, Dermatol & Pediat, San Diego, CA 92103 USA

[3] Henry Ford Hlth Syst, Dermatol Res, Detroit, MI USA

来源：

SEMINARS IN CUTANEOUS MEDICINE AND SURGERY | 2017年 / 36卷

关键词：

Atopic dermatitis; crisaborole; eczema; dupilumab; interleukin inhibition; OPA-15406; phosphodiesterase-4; inhibition; PHOSPHODIESTERASE-4; PDE4; INHIBITOR; CHILDREN; PLACEBO; AD;

D O I：

10.12788/j.sder.2017.012

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Several immunologic mediators-phosphodiesterase (PDE), interleukin (IL), small molecules, and Janus kinase-have been implicated in the pathogenesis of atopic dermatitis, and evidence has shown that blocking these mediators can help modify the disease process. Several new topical medications have been developed that target the enzyme PDE; crisaborole was recently approved by the US Food and Drug Administration (FDA) for the treatment of atopic dermatitis, and phase II studies have been completed on OPA-15406. The phase III clinical trial results of the systemic medication dupilumab, an inhibitor of the IL-4 receptor a subunit (which inhibits both IL-4 and IL-13 signaling), are currently being reviewed by the FDA. (C) 2017 published by Frontline Medical Communications

引用

页码：S45 / S48

页数：4

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