Asymmetric Fluorination Reactions promoted by Chiral Hydrogen Bonding-based Organocatalysts

被引：23

作者：

Auria-Luna, Fernando ^{[1
]}

Mohammadi, Somayeh ^{[2
]}

Divar, Masoumeh ^{[2
]}

Gimeno, M. Concepcion ^{[3
]}

Herrera, Raquel P. ^{[1
]}

机构：

[1] Univ Zaragoza, Lab Organocatalisis Asimetr, Dept Quim Organ, Inst Sintesis Quim & Catalisis Homogenea ISQCH,CS, C Pedro Cerbuna 12, Zaragoza 50009, Spain

[2] Shiraz Univ Med Sci, Med & Nat Prod Chem Res Ctr, Shiraz 7134853734, Iran

[3] Univ Zaragoza, Dept Quim Inorgan, Inst Sintesis Quim & Catalisis Homogenea ISQCH, CSIC, C Pedro Cerbuna 12, Zaragoza 50009, Spain

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2020年 / 362卷 / 23期

关键词：

fluorination; hydrogen-bond; organocatalysis; phosphoric acid; squaramide; (thio)urea; CATALYTIC ENANTIOSELECTIVE FLUORINATION; PHASE-TRANSFER CATALYSIS; BETA-KETO-ESTERS; MICHAEL ADDITION; PHOSPHORIC-ACID; CARBON-CARBON; MEDICINAL CHEMISTRY; BRONSTED ACID; CINCHONA ALKALOIDS; THIOUREA CATALYSTS;

D O I：

10.1002/adsc.202000848

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Fluorinated compounds can exhibit interesting biological properties. The importance of these species has made that the chemistry of fluorine has experienced a great development. On this review, the recent advances on asymmetric fluorination reactions promoted by chiral hydrogen bonding-based organocatalysts are discussed. Hence, examples using phosphoric acid, carboxylic acid, (thio)urea and squaramide derivatives are illustrated. The growth of this field is amazing. We have only considered pivotal works in which direct fluorination takes place using a fluorinating agent, leaving aside the reactions where a fluorine atom is incorporated from the beginning as part of other reactants. Herein, the scarce existing examples on this field of research have been compiled.

引用

页码：5275 / 5300

页数：26

共 199 条

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