Apolipoprotein ε4 Allele and Subjective Cognitive Functioning in Parents of Adults With Disabilities

被引:1
作者
Song, Jieun [1 ]
Mailick, Marsha R. [1 ]
Greenberg, Jan S. [1 ]
机构
[1] Univ Wisconsin, Waisman Ctr, 1500 Highland Ave,Room 557, Madison, WI 53705 USA
来源
JOURNALS OF GERONTOLOGY SERIES B-PSYCHOLOGICAL SCIENCES AND SOCIAL SCIENCES | 2020年 / 75卷 / 08期
关键词
Caregiving; Cognition; Gender; Genetic risk; Stress; DEVELOPMENTAL-DISABILITIES; EPISODIC MEMORY; CORTISOL-LEVELS; APOE GENOTYPE; DECLINE; HEALTH; CHILDREN; DISEASE; ASSOCIATION; MIDLIFE;
D O I
10.1093/geronb/gbaa061
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
Objectives: Parents of individuals with disabilities face ongoing responsibilities of providing care and support for their children, even during the child's adulthood. Past research has shown that this caregiving role is linked to chronic stress and subsequent adverse health outcomes for parents, including impaired cognition. This study examines the impacts of genetic risk for cognitive impairment (apolipoprotein [APOE] epsilon 4 allele) among parents of adults with disabilities and comparison parents whose adult children do not have disabilities. Method: We performed rank order regression analysis of data from the Wisconsin Longitudinal Study (2004-2006 and 2010-2012 surveys and DNA samples). Participants included parents of adults with disabilities (247 mothers and 159 fathers) and comparison parents whose adult children were not disabled (1,482 mothers and 954 fathers). Results: Mothers who had adult children with disabilities and who were APOE epsilon 4 carriers reported significantly declining levels of subjective cognitive functioning over time, but mothers of adults with disabilities who did not have the APOE epsilon 4 allele did not manifest this change. Among comparison group mothers, cognitive change over time was not a function of their APOE epsilon 4 carrier status. Fathers' cognitive function did not differ significantly by either parental status or APOE epsilon 4 carrier status. Discussion: The results show that older mothers of adults with disabilities are more susceptible to cognitive impairment than their age peers if they have the genetic risk factor of APOE epsilon 4 allele.
引用
收藏
页码:E189 / E197
页数:9
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