Membrane Estrogen Receptors: Their Role in Blood Pressure Regulation and Cardiovascular Disease

被引：38
作者：
Prabhushankar, Roopashree [1 ,2 ,3 ]
Krueger, Caroline [1 ,2 ,3 ]
Manrique, Camila [1 ,2 ,3 ]
机构：
[1] Diabet & Metab Dept Internal Med, Div Endocrinol, Columbia, MO 65212 USA
[2] Diabet & Cardiovasc Ctr, Columbia, MO 65212 USA
[3] Univ Missouri, Harry S Truman VA Med Ctr, Columbia, MO 65212 USA
来源：
CURRENT HYPERTENSION REPORTS | 2014年 / 16卷 / 01期
关键词：
Hypertension; Cardiovascular disease; Estrogen; Estrogen receptor alpha; GPER-1; G-PROTEIN; INDUCED HYPERTENSION; INSULIN-RESISTANCE; SEX-DIFFERENCES; POSITION PAPER; FEMALE RATS; ALPHA; CELLS; BETA; ESTRADIOL;
D O I：
10.1007/s11906-013-0408-6
中图分类号：
R6 [外科学];
学科分类号：
1002 ; 100210 ;
摘要：
Hypertension (HTN) is a leading risk factor for cardiovascular disease (CVD) and continues to affect millions of people in industrialized nations. The increasing prevalence of HTN is closely related to the growing prevalence of obesity. Despite heightened awareness of the disease, a significant percentage of patients are uncontrolled and are at higher risk of heart failure, stroke, and chronic kidney disease. Evidence of the cardiovascular protective role of estrogen in premenopausal females has brought attention to estrogen receptor activation as a treatment strategy for HTN. Estrogen promotes vasodilation and decreases inflammation and atherosclerosis. It also controls blood pressure via modulation of the activity of the renin-angiotensin-aldosterone system. The effects of estrogen on the vasculature are partly mediated via membrane receptors. Membrane estrogen receptor a and G-protein-coupled GPER-1 have been studied extensively in the vasculature. This review will describe the available evidence supporting the role of estrogen membrane receptors in blood pressure control and CVD.
引用
收藏
页数：7
相关论文
共 46 条
[21]   Forecasting the Future of Cardiovascular Disease in the United States A Policy Statement From the American Heart Association [J].
Heidenreich, Paul A. ;
Trogdon, Justin G. ;
Khavjou, Olga A. ;
Butler, Javed ;
Dracup, Kathleen ;
Ezekowitz, Michael D. ;
Finkelstein, Eric Andrew ;
Hong, Yuling ;
Johnston, S. Claiborne ;
Khera, Amit ;
Lloyd-Jones, Donald M. ;
Nelson, Sue A. ;
Nichol, Graham ;
Orenstein, Diane ;
Wilson, Peter W. F. ;
Woo, Y. Joseph .
CIRCULATION, 2011, 123 (08) :933-944
[22]   Attenuation of Salt-Induced Cardiac Remodeling and Diastolic Dysfunction by the GPER Agonist G-1 in Female mRen2.Lewis Rats [J].
Jessup, Jewell A. ;
Lindsey, Sarah H. ;
Wang, Hao ;
Chappell, Mark C. ;
Groban, Leanne .
PLOS ONE, 2010, 5 (11)
[23]   COMPARATIVE BINDING AFFINITY OF ESTROGENS AND ITS RELATION TO ESTROGENIC POTENCY [J].
KORENMAN, SG .
STEROIDS, 1969, 13 (02) :163-&
[24]   Cloning of a novel estrogen receptor expressed in rat prostate and ovary [J].
Kuiper, GGJM ;
Enmark, E ;
PeltoHuikko, M ;
Nilsson, S ;
Gustafsson, JA .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (12) :5925-5930
[25]   Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta [J].
Kuiper, GGJM ;
Carlsson, B ;
Grandien, K ;
Enmark, E ;
Haggblad, J ;
Nilsson, S ;
Gustafsson, JA .
ENDOCRINOLOGY, 1997, 138 (03) :863-870
[26]   Obesity-Related Hypertension: Pathogenesis, Cardiovascular Risk, and Treatment-A Position Paper of the The Obesity Society and the American Society of Hypertension [J].
Landsberg, Lewis ;
Aronne, Louis J. ;
Beilin, Lawrence J. ;
Burke, Valerie ;
Igel, Leon I. ;
Lloyd-Jones, Donald ;
Sowers, James .
OBESITY, 2013, 21 (01) :8-24
[27]   Reduced vasorelaxation to estradiol and G-1 in aged female and adult male rats is associated with GPR30 downregulation [J].
Lindsey, Sarah H. ;
da Silva, Ariel S. ;
Silva, Mauro S. ;
Chappell, Mark C. .
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2013, 305 (01) :E113-E118
[28]   Vasodilation in Response to the GPR30 Agonist G-1 is Not Different From Estradiol in the mRen2.Lewis Female Rat [J].
Lindsey, Sarah H. ;
Carver, Kyle A. ;
Prossnitz, Eric R. ;
Chappell, Mark C. .
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 2011, 57 (05) :598-603
[29]   Chronic Treatment with the G Protein-Coupled Receptor 30 Agonist G-1 Decreases Blood Pressure in Ovariectomized mRen2.Lewis Rats [J].
Lindsey, Sarah Hoffmann ;
Cohen, Jonathan A. ;
Brosnihan, K. Bridget ;
Gallagher, Patricia E. ;
Chappell, Mark C. .
ENDOCRINOLOGY, 2009, 150 (08) :3753-3758
[30]   Deletion of the G Protein-Coupled Receptor 30 Impairs Glucose Tolerance, Reduces Bone Growth, Increases Blood Pressure, and Eliminates Estradiol-Stimulated Insulin Release in Female Mice [J].
Martensson, Ulrika E. A. ;
Salehi, S. Albert ;
Windahl, Sara ;
Gomez, Maria F. ;
Sward, Karl ;
Daszkiewicz-Nilsson, Joanna ;
Wendt, Anna ;
Andersson, Niklas ;
Hellstrand, Per ;
Grande, Per-Olof ;
Owman, Christer ;
Rosen, Clifford J. ;
Adamo, Martin L. ;
Lundquist, Ingmar ;
Rorsman, Patrik ;
Nilsson, Bengt-Olof ;
Ohlsson, Claes ;
Olde, Bjorn ;
Leeb-Lundberg, L. M. Fredrik .
ENDOCRINOLOGY, 2009, 150 (02) :687-698
12345