DESIGN AND SYNTHESIS OF NEW HYBRID TRIAZINE-INDOLE DERIVATIVES AS POTENTIAL ANTIMICROBIAL AGENTS AGAINST HOSPITAL RESISTANT STRAINS

被引：8
作者：
Al-Qawasmeh, Raed A. [1 ]
Khanfar, Monther A. [1 ]
Semreen, Mohamad H. [2 ,3 ]
Abu Odeh, Raed [4 ]
Al-Tel, Taleb H. [2 ,3 ]
机构：
[1] Univ Jordan, Dept Chem, Amman 11942, Jordan
[2] Univ Sharjah, Sharjah Inst Med Res, Sharjah, U Arab Emirates
[3] Univ Sharjah, Coll Pharm, Sharjah, U Arab Emirates
[4] Univ Sharjah, Dept Med Lab Technol, Coll Hlth Sci, Sharjah, U Arab Emirates
来源：
HETEROCYCLES | 2013年 / 87卷 / 11期
基金：
新加坡国家研究基金会;
关键词：
D O I：
10.3987/COM-13-12825
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A new series of antimicrobial [2-(5,6-diary1-1,2,4-triazin-3-y1)-1H-indole] have been synthesized via microwave technology. The synthesized compounds were found to be potent against various clinical isolates of Gram-positive and Gram-negative bacteria as well as hospital resistant strains, MRSA and MSSA when compared to the drugs Cephtriaxone, Gentamycin and Levofloxacin.
引用
收藏
页码：2385 / 2394
页数：10
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