Symptoms of anxiety and depression and risk of acute myocardial infarction: the HUNT 2 study

被引：65

作者：

Gustad, Lise Tuset ^{[1
,2
]}

Laugsand, Lars Erik ^{[3
,4
]}

Janszky, Imre ^{[3
,5
]}

Dalen, Havard ^{[1
,6
,7
]}

Bjerkeset, Ottar ^{[2
,8
]}

机构：

[1] Nord Trondelag Hosp Trust, Levanger Hosp, Dept Internal Med, N-7600 Levanger, Norway

[2] Norwegian Univ Sci & Technol NTNU, Dept Neurosci, Trondheim, Norway

[3] NTNU, Dept Publ Hlth & Gen Practice, Trondheim, Norway

[4] St Olavs Hosp, Dept Internal Med, Trondheim, Norway

[5] Karolinska Inst, Dept Publ Hlth Sci, Stockholm, Sweden

[6] NTNU, MI Lab, Trondheim, Norway

[7] NTNU, Dept Circulat & Med Imaging, Trondheim, Norway

[8] Nord Trondelag Hosp Trust, Levanger Hosp, Dept Res & Dev, Levanger, Norway

来源：

EUROPEAN HEART JOURNAL | 2014年 / 35卷 / 21期

关键词：

Depression; Anxiety; Prospective; Risk; Acute myocardial infarction; Epidemiology;

D O I：

10.1093/eurheartj/eht387

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Aims The nature of the association of depression and anxiety with risk for acute myocardial infarction (AMI) remains unclear. We aimed to study the prospective association of single and recurrent self-reported symptoms of anxiety and depression with a risk of AMI in a large Norwegian population based cohort. Methods and results In the second wave of the Nord-Trondelag Health Study (HUNT2, 1995-97) baseline data on anxiety and depression symptoms, sociodemographic variables, health status including cardiovascular risk factors and common chronic disorders were registered for 57 953 adult men and women free of cardiovascular disease. The cohort was followed up during a mean (SD) 11.4 (2.9) years for a first AMI from baseline through 2008. A total of 2111 incident AMIs occurred, either identified at hospitals or by the National Cause of Death Registry. The multi-adjusted hazard ratios were 1.31 (95% CI 1.03-1.66) for symptoms of depression and 1.25 (CI 0.99-1.57) for anxiety. Two episodes of mixed symptoms of anxiety and depression (MSAD), reported 10 years apart, increased the risk for AMI by 52% (11-108%). After exclusion of the first 5 years of follow-up, the association of depression symptoms with AMI risk was attenuated. Relative risk for AMI with anxiety symptoms and MSAD weakened when participants with chronic disorders were excluded. Conclusion Self-reported symptoms of depression and anxiety, especially if recurrent, were moderately associated with the risk of incident AMI. We had some indications that these associations might partly reflect reverse causation or confounding from common chronic diseases.

引用

页码：1394 / 1403

页数：10

共 39 条

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