Use of diuretics during pregnancy

被引：0

作者：

Al-Balas, Mosa'b ^{[1
]}

Bozzo, Pina ^{[1
]}

Einarson, Adrienne ^{[1
]}

机构：

[1] Univ Toronto, Fac Pharm, Toronto, ON M5S 1A1, Canada

来源：

CANADIAN FAMILY PHYSICIAN | 2009年 / 55卷 / 01期

关键词：

ANTIHYPERTENSIVE DRUGS; THIAZIDE DIURETICS; PLASMA-VOLUME; HYPERTENSION;

D O I：

暂无

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

QUESTION Several of my pregnant patients use diuretics for hypertension. I have heard that diuretics cannot be used in pregnancy because of the reduction of plasma volume and the potential for decreasing placental perfusion, as well as a possible diabetogenic effect. ANSWER Many studies-including a meta-analysis of almost 7000 neonates exposed to diuretics during pregnancy-did not find an increased risk of adverse effects, such as birth defects, fetal growth restriction, thrombocytopenia, or diabetes, among neonates exposed to diuretics in utero.

引用

页码：44 / 45

页数：2

共 11 条

[1] Maternal hemodynamic changes associated with furosemide treatment
Carr, Darcy B.
Gavrila, Daniel
Brateng, Debra
Easterling, Thomas R.
[J]. HYPERTENSION IN PREGNANCY, 2007, 26 (02) : 173 - 178
[2] OVERVIEW OF RANDOMIZED TRIALS OF DIURETICS IN PREGNANCY
COLLINS, R
YUSUF, S
PETO, R
[J]. BMJ-BRITISH MEDICAL JOURNAL, 1985, 290 (6461): : 17 - 23
[3] METABOLIC-CLEARANCE RATE OF DEHYDROISOANDROSTERONE SULFATE .3. EFFECT OF THIAZIDE DIURETICS IN NORMAL AND FUTURE PREECLAMPTIC PREGNANCIES
GANT, NF
MADDEN, JD
SIITERI, PK
MACDONALD, PC
[J]. AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1975, 123 (02) : 159 - 163
[4] The addition of a diuretic to anti-hypertensive therapy for early severe hypertension in pregnancy
Hall, DR
Odendaal, HJ
[J]. INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS, 1998, 60 (01) : 63 - 64
[5] Treating hypertension in women of child-bearing age and during pregnancy
Magee, LA
[J]. DRUG SAFETY, 2001, 24 (06) : 457 - 474
[6] Effect of diuretics on fetal growth: A drug effect or confounding by indication? Pooled Danish and Scottish cohort data
Olesen, C
de Vries, CS
Thrane, N
MacDonald, TM
Larsen, H
Sorensen, HT
[J]. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2001, 51 (02) : 153 - 157
[7] Update on the use of antihypertensive drugs in pregnancy
Podymow, Tiina
August, Phyllis
[J]. HYPERTENSION, 2008, 51 (04) : 960 - 969
[8] MECHANISM OF ANTIHYPERTENSIVE EFFECT OF THIAZIDE DIURETICS
SHAH, S
KHATRI, I
FREIS, ED
[J]. AMERICAN HEART JOURNAL, 1978, 95 (05) : 611 - 618
[9] EFFECTS OF DIURETICS ON PLASMA-VOLUME IN PREGNANCIES WITH LONG-TERM HYPERTENSION
SIBAI, BM
GROSSMAN, RA
GROSSMAN, HG
[J]. AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1984, 150 (07) : 831 - 835
[10] SIBAI BM, 1982, OBSTET GYNECOL, V60, P174

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