Inhibition of Mnk-eIF4E pathway sensitizes the efficacy to chemotherapy in anaplastic thyroid cancer

被引：13
|
作者：
Hu, Kun [1 ]
Zhang, Juan [2 ]
Yu, Min [3 ]
Xiong, Chang'e [4 ]
机构：
[1] Yangtze Univ, Jingzhou Cent Hosp, Thyroid Surg Dept, Clin Med Coll 2, Jingzhou, Peoples R China
[2] Yangtze Univ, Jingzhou Cent Hosp, Dept Endocrinol, Clin Med Coll 2, Jingzhou, Peoples R China
[3] Yangtze Univ, Jingzhou Cent Hosp, Galactophore Dept, Clin Med Coll 2, Jingzhou, Peoples R China
[4] Hubei Univ Sci & Technol, Sch Basic Med Sci, Xianning, Peoples R China
来源：
FUTURE ONCOLOGY | 2017年 / 13卷 / 06期
关键词：
chemotherapy; eIF4E; Mnk; thyroid cancer; CELL-GROWTH; TRANSLATION; APOPTOSIS; PHOSPHORYLATION; PROGRESSION; CARCINOMA; THERAPY; EIF4E; LINES; MNKS;
D O I：
10.2217/fon-2016-0320
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Aim: We investigated whether MAPK-interacting kinase (Mnk) inhibition sensitizes anaplastic thyroid cancer (ATC) cellular response to chemotherapy. Materials & methods: In vitro and in vivo methods were used to examine the combinatory effects of cisplatin with Mnk inhibition and its underlying mechanism. Results: Mnk inhibition by pharmacological or genetic approaches inhibits proliferation and induces apoptosis of ATC cells and enhances the effects of cisplatin in in vitro and in vivo. Mechanistically, cisplatin increases eIF4E phosphorylation in a dose-and time-dependent manner in ATC cells. Mnk inhibitors sensitize the efficacy of cisplatin by inhibiting cisplatin-induced eIF4E phosphorylation. Conclusion: Targeting Mnk-eIF4E pathway provides a therapeutic strategy by sensitizing ATC response to chemotherapeutic drug.
引用
收藏
页码：489 / 498
页数：10
相关论文
共 50 条
  • [41] BET inhibitors induce Rac1-dependent MNK and eIF4E phosphorylation in cancer cells
    Thao Pham
    Decant, Brian T.
    Kumar, Krishan
    Shang, Meng
    Matsangou, Maria
    Ebine, Kazumi
    Munshi, Hidayatullah G.
    CANCER RESEARCH, 2018, 78 (13)
  • [42] Inhibition of MAPKinase pathway sensitizes thyroid cancer cells to ABT-737 induced apoptosis
    Gunda, Viswanath
    Sarosiek, Kristopher A.
    Brauner, Eran
    Kim, Yon Seon
    Amin, Salma
    Zhou, Zhiheng
    Letai, Antony
    Parangi, Sareh
    CANCER LETTERS, 2017, 395 : 1 - 10
  • [43] Inhibiting MNK Selectively Targets Cervical Cancer via Suppressing eIF4E-Mediated β-Catenin Activation
    Zhang, Weijia
    Su, Xiaoyan
    Li, Shuang
    Wang, Ya
    Wang, Qian
    Zeng, Hai
    AMERICAN JOURNAL OF THE MEDICAL SCIENCES, 2019, 358 (03): : 227 - 234
  • [44] The retinamide VNLG-152 inhibits f-AR/AR-V7 and MNK-eIF4E signaling pathways to suppress EMT and castration-resistant prostate cancer xenograft growth
    Ramamurthy, Vidya P.
    Ramalingam, Senthilmurugan
    Gediya, Lalji K.
    Njar, Vincent C. O.
    FEBS JOURNAL, 2018, 285 (06) : 1051 - 1063
  • [45] Pifithrin sensitizes human cholangiocarcinoma cells to genicitabine chemotherapy by a mechanism involving the translational regulator eIF4E
    Wehbe, Hania
    Meng, Fanyin
    Henson, Roger
    Mize-Berge, Janna M.
    Patel, Tushar
    GASTROENTEROLOGY, 2006, 130 (04) : A760 - A760
  • [46] Selective inhibition of DNA ligase IV provides additional efficacy to the treatment of anaplastic thyroid cancer
    Sriramareddy, Sathya Neelature
    Jamakhani, Majeed
    Vilanova, Lea
    Brossel, Helene
    Staumont, Bernard
    Hamaidia, Malik
    FRONTIERS IN ONCOLOGY, 2024, 14
  • [47] Activation of MNK2/eIF4E Pathway by the Splicing Factor SRSF1 Supports Pancreatic Cancer Cell Survival to Genotoxic Stress
    Adesso, L.
    Calabretta, S.
    Barbagallo, F.
    Pilozzi
    Capurso, G.
    Geremia, R.
    Delle Fave, G.
    Sette, C.
    PANCREAS, 2011, 40 (08) : 1308 - 1308
  • [48] The MNK1/2-eIF4E Axis Supports Immune Suppression and Metastasis in Postpartum Breast Cancer
    Guo, Qianyu
    Bartish, Margarita
    Goncalves, Christophe
    Huang, Fan
    Smith-Voudouris, Julian
    Krisna, Sai Sakktee
    Preston, Samuel E. J.
    Emond, Audrey
    Li, Vivian Z.
    Duerr, Claudia U.
    Gui, Yirui
    Cleret-Buhot, Aurelie
    Thebault, Pamela
    Lefrere, Hanne
    Lenaerts, Liesbeth
    Plourde, Dany
    Su, Jie
    Mindt, Barbara C.
    Hewgill, Shannon A.
    Cotechini, Tiziana
    Hindmarch, Charles C. T.
    Yang, William
    Khoury, Elie
    Zhan, Yao
    Narykina, Valeria
    Wei, Yuhong
    Floris, Giuseppe
    Basik, Mark
    Amant, Frederic
    Quail, Daniela F.
    Lapointe, Rejean
    Fritz, Jorg H.
    del Rincon, Sonia, V
    Miller, Wilson H., Jr.
    CANCER RESEARCH, 2021, 81 (14) : 3876 - 3889
  • [49] Diallyl sulfide induces growth inhibition and apoptosis of anaplastic thyroid cancer cells by mitochondrial signaling pathway
    Shin, Hyang Ae
    Cha, Yun Yi
    Park, Mun Su
    Kim, Jae Myeong
    Lim, Young Chang
    ORAL ONCOLOGY, 2010, 46 (04) : E15 - E18
  • [50] Role of MNK/eIF4E pathway in CD4+Th2 cytokine-induced lung fibrosis in chronic allergic asthma
    Fattahi, Fatemeh
    Vallance, Laura
    Walker, Natalie
    Holden, Julia
    Huang, Steven
    Atasoy, Ulus
    JOURNAL OF IMMUNOLOGY, 2024, 212 (01):
12345