Synthesis and Structure Elucidation of New Regioisomeric 2-Alkylamino-6-aryl-8,9-dihydropyrimido[4,5-b][1,4]diazepin-4(7H)-ones

被引：3
|
作者：
Insuasty, Braulio [1 ]
Orozco, Fabian [2 ]
Quiroga, Jairo [1 ]
Abonia, Rodrigo [1 ]
Nogueras, Manuel [3 ]
Cobo, Justo [3 ]
机构：
[1] Univ Valle, Heterocycl Cpds Res Grp, Dept Chem, Cali 25360, Colombia
[2] Univ Nacl Colombia, Dept Chem, Bogota 14490, DC, Colombia
[3] Univ Jaen, Dept Inorgan & Organ Chem, Jaen 23071, Spain
来源：
JOURNAL OF HETEROCYCLIC CHEMISTRY | 2014年 / 51卷 / 01期
关键词：
ORGANIC SYNTHESES; MICROWAVE; DERIVATIVES;
D O I：
10.1002/jhet.1778
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Novel 2-Alkylamino-6-aryl-8,9-dihydropyrimido[4,5-b][1,4]diazepin-4(7H)-ones 5a, 5b, 5c, 5d, 5e, 5f, 5g, 5h, 5i, 5j, 5k, 5l, 5m, 5n, 5o were prepared regioselectively by the reaction of 2-alkylamino-5,6-diaminopyrimidin-4(3H)-ones 3a, 3b, 3c and dimethylamino propiophenones (Mannich bases) 4a, 4b, 4c, 4d, 4e, 4f. The combination of conventional heating and microwave irradiation approaches provided the possibility of working with both stable and sensitive diaminopyrimidines by controlling parameters such as reaction rates, temperature, and power of irradiation. All products were fully characterized by detailed NMR measurements.
引用
收藏
页码：196 / 202
页数：7
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