The Evolution of Human Probiotics: Challenges and Prospects

被引：67

作者：

Trush, Elizaveta A. ^{[1
]}

Poluektova, Elena A. ^{[1
]}

Beniashvilli, Allan G. ^{[2
]}

Shifrin, Oleg S. ^{[1
]}

Poluektov, Yuri M. ^{[3
]}

Ivashkin, Vladimir T. ^{[1
]}

机构：

[1] Sechenov Univ, Fed State Autonomous Educ Inst Higher Educ IM Sec, Moscow State Med Univ 1, Minist Hlth Russian Federat, Moscow, Russia

[2] Minist Hlth Russian Federat, Mental Hlth Res Ctr, Fed State Budgetary Sci Inst, Moscow, Russia

[3] Russian Acad Sci, Engelhardt Inst Mol Biol, Moscow, Russia

来源：

PROBIOTICS AND ANTIMICROBIAL PROTEINS | 2020年 / 12卷 / 04期

关键词：

Monostrain and multistrain probiotics; Biofilm; Planktonic cells; Efficacy; IRRITABLE-BOWEL-SYNDROME; PSEUDOMONAS-AERUGINOSA; HEPATIC-ENCEPHALOPATHY; BIOFILM; ALGINATE; SYSTEM; GROWTH; ENCAPSULATION; COMBINATION; INHIBITION;

D O I：

10.1007/s12602-019-09628-4

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

In recent years, the intestinal microbiota has been found to greatly influence a number of biological processes important for human health and longevity. Microbial composition changes easily in response to external factors, such as an unbalanced diet, lack of physical activity, and smoking. Probiotics are a key factor in maintaining the optimal composition of the intestinal microbiota. However, a number of important questions related to probiotics, such as indication for prescription, comparative efficacy of monostrain and multistrain probiotics, methods of delivery, and shelf life, remain unresolved. The aim of this review is to highlight existing issues regarding probiotic production and their prescription. The review presents the most recent findings regarding advantages and efficacy of monostrain and multistrain probiotics, preservation of probiotic strains in capsules and microcapsules, production of probiotics in the form of biofilms for improved efficacy and survival, and results of clinical studies evaluating the benefits of probiotics against different pathologies. We believe that this work will be of interest to physicians and researchers alike and will promote the development of new probiotics and ensuing regimens aimed at the treatment of various diseases.

引用

页码：1291 / 1299

页数：9

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