Aromatic Schiff bases and 2,3-disubstituted-1,3-thiazolidin-4-one derivatives as antiinflammatory agents

被引：76

作者：

Vazzana, I

Terranova, E

Mattioli, F

Sparatore, F ^{[1
]}

机构：

[1] Univ Genoa, Dipartimento Sci Farmaceut, Viale Benedetto XV 3, I-16132 Genoa, Italy

[2] Univ Genoa, Dipartimento Med Interna, Sez Farmacol & Tossicol Clin, I-16132 Genoa, Italy

来源：

ARKIVOC | 2004年

关键词：

aromatic Schiff bases; 2,3-diaryl-1,3-thiazolidinon-4-one derivatives; antiinflammatory agents; antinociceptive agents;

D O I：

10.3998/ark.5550190.0005.531

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two small sets of aromatic Schiff bases and 2,3-diaryl-1,3-thiazolidin-4-one derivatives have been prepared and tested for antiinflammatory and antinociceptive activities. The thiazolidinone derivatives have been obtained from the azomethines through the addition of alpha-mercaptoacetic acid. Both types of compounds displayed good level of activity against carrageenan induced edema in rat hind paw, while only moderate activity was observed in the writhing test in mice.

引用

页码：364 / 374

页数：11

共 18 条

[1] In vitro evaluation of thiazolyl and benzothiazolyl Schiff bases on pig cartilage [J].