Korean Pine Nut Oil Attenuated Hepatic Triacylglycerol Accumulation in High-Fat Diet-Induced Obese Mice

被引:21
作者
Park, Soyoung [1 ]
Shin, Sunhye [1 ]
Lim, Yeseo [1 ]
Shin, Jae Hoon [2 ]
Seong, Je Kyung [2 ,3 ,4 ]
Han, Sung Nim [1 ,5 ]
机构
[1] Seoul Natl Univ, Coll Human Ecol, Dept Food & Nutr, Seoul 151742, South Korea
[2] Seoul Natl Univ, Program Vet Sci BK21, Coll Vet Med, Seoul 151742, South Korea
[3] Seoul Natl Univ, Res Inst Vet Sci, Seoul 151742, South Korea
[4] Seoul Natl Univ, BioMAX Inst, Seoul 151742, South Korea
[5] Seoul Natl Univ, Res Inst Human Ecol, Seoul 151742, South Korea
来源
NUTRIENTS | 2016年 / 8卷 / 01期
基金
新加坡国家研究基金会;
关键词
pine nut oil; high-fat diet; obesity; hepatic steatosis; SIRT3; MITOCHONDRIAL BETA-OXIDATION; CONJUGATED LINOLEIC-ACID; LIVER-DISEASE; FETUIN-A; LIPOPROTEIN METABOLISM; MOLECULAR-MECHANISMS; CALORIC RESTRICTION; WEIGHT-GAIN; IN-VITRO; SEED OIL;
D O I
10.3390/nu8010059
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Korean pine nut oil (PNO) has been reported to influence weight gain and lipid metabolism. We examined whether PNO replacement in a high-fat diet (HFD) can ameliorate HFD-induced hepatic steatosis. Five-week-old male C57BL mice were fed control diets containing 10% of the energy from fat from PNO or soybean oil (SBO) (PC, SC) or HFDs with 45% of the energy from fat, with 10% from PNO or SBO and 35% from lard (PHFD, SHFD), for 12 weeks. Body weight gain and amount of white adipose tissue were lower in PHFD (10% and 18% lower, respectively) compared with SHFD. Hepatic triacylglycerol (TG) level was significantly lower in PHFD than the SHFD (26% lower). PNO consumption upregulated hepatic ACADL mRNA levels. The hepatic PPARG mRNA level was lower in the PC than in the SC. Expression of the sirtuin (SIRT) 3 protein in white adipose tissue was down-regulated in the SHFD and restored in the PHFD to the level in the lean control mice. SIRT 3 was reported to be upregulated under conditions of caloric restriction (CR) and plays a role in regulating mitochondrial function. PNO consumption resulted in lower body fat and hepatic TG accumulation in HFD-induced obesity, which seemed to be associated with the CR-mimetic response.
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页数:15
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