Cancer Chemopreventive Activity of Xanthones from Calophyllum elatum

被引：0
作者：
Ito, Chihiro [1 ]
Matsui, Takuya [1 ,2 ]
Kobayashi, Takashi [1 ]
Tokuda, Harukuni [3 ]
Shanmugam, Sivabalan [4 ]
Itoigawa, Masataka [5 ]
机构：
[1] Meijo Univ, Fac Pharm, Tempaku Ku, Nagoya, Aichi 4688503, Japan
[2] Aichi Med Univ, Sch Med, Dept Physiol, Nagakute, Aichi 4801195, Japan
[3] Kyoto Univ, Grad Sch Agr, Div Food Sci & Biotechnol, Organ Chem Life Sci, Kyoto 6068502, Japan
[4] Annamalai Univ, Fac Sci, Annamalainagar 608002, Tamil Nadu, India
[5] Tokai Gakuen Univ, Sch Sport & Hlth Sci, 21-233 Nishinohora, Miyoshi, Aichi 4700207, Japan
来源：
NATURAL PRODUCT COMMUNICATIONS | 2018年 / 13卷 / 04期
关键词：
Calophyllum elatum; Guttiferae; Xanthones; Isogarciniaxanthone E; Cancer chemopreventive activity; CHEMICAL-CONSTITUENTS; STRUCTURE ELUCIDATION; STEM BARK; PLANTS;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
In our continuing search for compounds with antitumor-promoting activity, we screened eight xanthones isolated from Calophyllum elatum Bedd. (Guttiferae) by examining their possible inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in Raji cells. Several compounds tested in this study showed inhibitory activity against EBV, without showing any cytotoxicity. Isogarciniaxanthone E (2) showed more potent activity than any of the other compounds tested. Furthermore, isogarciniaxanthone E (2) exhibited a marked inhibitory effect on mouse skin tumor promotion in an in vivo two-stage carcinogenesis test.
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页码：447 / 449
页数：3
相关论文
共 20 条
[1]   Trypanocidal constituents in plants 2.: Xanthones from the stem bark of Garcinia subelliptica [J].
Abe, F ;
Nagafuji, S ;
Okabe, H ;
Higo, H ;
Akahane, H .
BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2003, 26 (12) :1730-1733
[2]  
Aminudin NI, 2015, NAT PROD COMMUN, V10, P1585
[3]   Chemical and Pharmacological Aspects of the Genus Calophyllum [J].
Cechinel Filho, Valdir ;
Meyre-Silva, Christiane ;
Niero, Rivaldo .
CHEMISTRY & BIODIVERSITY, 2009, 6 (03) :313-327
[4]   Prenylated xanthones with NGF-potentiating activity from Garcinia xanthochymus [J].
Chanmahasathien, W ;
Li, YS ;
Satake, M ;
Oshima, Y ;
Ruangrungsi, N ;
Ohizumi, Y .
PHYTOCHEMISTRY, 2003, 64 (05) :981-986
[5]   2 NEW XANTHONES FROM THE ROOT BARK OF GARCINIA-SUBELLIPTICA [J].
IINUMA, M ;
TOSA, H ;
TANAKA, T ;
ASAI, F ;
SHIMANO, R .
HETEROCYCLES, 1995, 40 (01) :279-284
[6]   Five new xanthones from Garcinia dulcis [J].
Iinuma, M ;
Ito, T ;
Tosa, H ;
Tanaka, T ;
Riswan, S .
JOURNAL OF NATURAL PRODUCTS, 1996, 59 (05) :472-475
[7]   Chemical constituents of Calophyllum brasiliense.: 2.: Structure of three new coumarins and cancer chemopreventive activity of 4-substituted coumarins [J].
Ito, C ;
Itoigawa, M ;
Mishina, Y ;
Cechinel, V ;
Enjo, F ;
Tokuda, H ;
Nishino, H ;
Furukawa, H .
JOURNAL OF NATURAL PRODUCTS, 2003, 66 (03) :368-371
[8]   Chemical constituents of Garcinia fusca:: Structure elucidation of eight new xanthones and their cancer chemopreventive activity [J].
Ito, C ;
Itoigawa, M ;
Takakura, T ;
Ruangrungsi, N ;
Enjo, F ;
Tokuda, H ;
Nishino, H ;
Furukawa, H .
JOURNAL OF NATURAL PRODUCTS, 2003, 66 (02) :200-205
[9]   Chemical constituents of Calophyllum brasiliensis:: Structure elucidation of seven new xanthones and their cancer chemopreventive activity [J].
Ito, C ;
Itoigawa, M ;
Mishina, Y ;
Cechinel, V ;
Mukainaka, T ;
Tokuda, H ;
Nishino, H ;
Furukawa, H .
JOURNAL OF NATURAL PRODUCTS, 2002, 65 (03) :267-272
[10]   Xanthones as inhibitors of Epstein-Barr virus activation [J].
Ito, C ;
Itoigawa, M ;
Furukawa, H ;
Rao, KS ;
Enjo, F ;
Bu, P ;
Takayasu, J ;
Tokuda, H ;
Nishino, H .
CANCER LETTERS, 1998, 132 (1-2) :113-117
12