Role of carbon monoxide in cardiovascular function

被引:116
作者
Durante, WiRiam
Johnson, Fruzsina K.
Johnson, Robert A.
机构
[1] Univ Missouri, Sch Med, Dept Med Pharmacol & Physiol, Columbia, MO 65212 USA
[2] Univ Texas, Hlth Sci Ctr, Dept Surg, San Antonio, TX 78284 USA
[3] Trauma Inst San Antonio, TRISAT, San Antonio, TX USA
关键词
carbon monoxide; heme oxygenase-1; vascular smooth muscle; endothelium; atherosclerosis; restenosis; ischemia-reperfusion; blood pressure;
D O I
10.1111/j.1582-4934.2006.tb00427.x
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Carbon monoxide (CO) is an endogenously derived gas formed from the breakdown of heme by the enzyme heme oxygenase. Although long considered an insignificant and potentially toxic waste product of heme catabolism, CO is now recognized as a key signaling molecule that regulates numerous cardiovascular functions. Interestingly, alterations in CO synthesis are associated with many cardiovascular disorders, including atherosclerosis, septic shock, hypertension, metabolic syndrome, and ischemia-reperftision injury. Significantly, restoration of physiologic CO levels exerts a beneficial effect in many of these settings, suggesting a crucial role for CO in maintaining cardiovascular homeostasis. In this review, we outline the actions of CO in the cardiovascular system and highlight this gas as a potential therapeutic target in treating a multitude of cardiovascular disorders.
引用
收藏
页码:672 / 686
页数:15
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