Mechanical property predictions for polymorphs of sulphathiazole and carbamazepine

被引：50

作者：

Roberts, RJ ^{[1
]}

Payne, RS ^{[1
]}

Rowe, RC ^{[1
]}

机构：

[1] ZENECA Pharmaceut, Macclesfield SK10 2NA, Cheshire, England

来源：

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES | 2000年 / 9卷 / 03期

关键词：

polymorphism; mechanical property prediction; morphology;

D O I：

10.1016/S0928-0987(99)00065-2

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The mechanical properties of polymorphs of sulphathiazole and carbamazepine have been determined experimentally by three-point beam bending. It is shown that the mechanical properties of sulphathiazole and carbamazepine polymorphs can be predicted using the atom-atom potential model applied to lattice dynamics, as long as account is taken of crystal morphology when considering the experimental results. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：277 / 283

页数：7

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