Synthesis and anti-inflammatory and analgesic activities of pyridyloxy- and phenoxyalkanoic acid derivatives

被引：2

作者：

Shin, KH

Lim, SS

Jung, SH

Ji, J

Lee, EP

Kim, DC

Shin, KJ

Kim, DJ

Park, SW

机构：

[1] Seoul Natl Univ, Inst Nat Prod Res, Chong Ro Ku, Seoul 110460, South Korea

[2] Korea Inst Sci & Technol, Div Appl Sci, Seoul, South Korea

来源：

ARCHIVES OF PHARMACAL RESEARCH | 2000年 / 23卷 / 01期

关键词：

pyridyloxyalkanate; pyridyloxyphenoxyalkanate; phenoxylphenoxyalkanate; antiinflammatory activity; analgesic activity; carrageenin-induced paw edema; acetic acid writhing syndrome; tail clip pressure test;

D O I：

10.1007/BF02976459

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Synthesis of pyridyloxy-, pyridyloxyphenoxy- and phenoxylphenoxyalkanate derivatives and their anti-inflammatory and analgesic activities were investigated. Analysis of structure-activity relationships showed that in pyridyloxyalkanoic acid derivatives anti-edematous potency was associated with the presence of chlorophenoxypropionic acid moiety and 2-nitrated methyl propionates contributed to the analgesic activity.

引用

页码：17 / 21

页数：5

共 11 条

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Domenjoz R, 1966, Adv Pharmacol, V4, P143, DOI 10.1016/S1054-3589(08)60099-X

[2] The influence of the arsono group on the activity of nuclear chlorine [J].