Carbohydrate-deficient transferrin (CDT) as a marker of alcohol abuse: A critical review of the literature 2001-2005

被引：131

作者：

Bortolotti, Federica ^{[1
]}

De Paoli, Giorgia ^{[1
]}

Tagliaro, Franco ^{[1
]}

机构：

[1] Univ Verona, Dept Publ Hlth Med, Chair Forens Med, Policlin GB Rossi, I-37134 Verona, Italy

来源：

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES | 2006年 / 841卷 / 1-2期

关键词：

carbohydrate deficient transferrin; alcohol abuse; biomarkers; analysis;

D O I：

10.1016/j.jchromb.2006.05.005

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The diagnosis of alcohol abuse based on objective data is a necessary requirement in both clinical and forensic environments. Among the different biomarkers of chronic alcohol abuse, carbohydrate-deficient transferrin (CDT) is world wide recognized as the most reliable indicator. However, several problems about the real meaning of CDT and the reliability of its use for the diagnosis of alcohol abuses are still open, as reported by numerous research articles and reviews. The present article presents a critical review of the literature on CDT appeared in the period from 2001 to 2005 (included). The article is organized in the following sections: (1) introduction, (2) definition and structure of human serum CDT, (3) pathomechanisms of the ethanol-induced CDT increase, (4) preanalysis, (5) analysis, (6) data interpretation, (7) review papers, (8) conclusions. As many as 127 papers appeared in the international literature and retrieved by the search engines PubMed and Scopus are quoted. (c) 2006 Elsevier B.V. All rights reserved.

引用

页码：96 / 109

页数：14

共 128 条

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[5]

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[7]

[Anonymous], MED SCI MONIT

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