Reflex control of immunity

被引：793

作者：

Tracey, Kevin J. ^{[1
]}

机构：

[1] Feinstein Inst Med Res, Manhasset, NY 11030 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2009年 / 9卷 / 06期

基金：

美国国家卫生研究院;

关键词：

HEART-RATE-VARIABILITY; CHOLINERGIC ANTIINFLAMMATORY PATHWAY; TUMOR-NECROSIS-FACTOR; NICOTINIC ACETYLCHOLINE-RECEPTORS; VAGUS NERVE-STIMULATION; COLLAGEN-INDUCED ARTHRITIS; SYSTEMIC INFLAMMATORY RESPONSE; C-REACTIVE PROTEIN; FACTOR-ALPHA; KAPPA-B;

D O I：

10.1038/nri2566

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Inflammation can cause damage and even death. What controls this primitive and potentially lethal innate immune response to injury and infection? Molecular and neurophysiological studies during the past decade have revealed a pivotal answer: immunity is coordinated by neural circuits that operate reflexively. The afferent arc of the reflex consists of nerves that sense injury and infection. This activates efferent neural circuits, including the cholinergic anti-inflammatory pathway, that modulate immune responses and the progression of inflammatory diseases. It might be possible to develop therapeutics that target neural networks for the treatment of inflammatory disorders.

引用

收藏

页码：418 / 428

页数：11

相关论文

共 101 条

[31] Vagus nerve integrity and experimental colitis [J].

Ghia, Jean-Eric ;

Blennerhassett, Patricia ;

Collins, Stephen M. .

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2007, 293 (03) :G560-G567

[32]

Goehler LE, 1999, J NEUROSCI, V19, P2799

[33] Vagal paraganglia bind biotinylated interleukin-1 receptor antagonist: A possible mechanism for immune-to-brain communication [J].

Goehler, LE ;

Relton, JK ;

Dripps, D ;

Kiechle, R ;

Tartaglia, N ;

Maier, SF ;

Watkins, LR .

BRAIN RESEARCH BULLETIN, 1997, 43 (03) :357-364

[34] Exercise training modulates cytokines activity in coronary heart disease patients [J].

Goldhammer, E ;

Tanchilevitch, A ;

Maor, I ;

Beniamini, Y ;

Rosenschein, U ;

Sagiv, M .

INTERNATIONAL JOURNAL OF CARDIOLOGY, 2005, 100 (01) :93-99

[35] Efferent vagal fibre stimulation blunts nuclear factor-κB activation and protects against hypovolemic hemorrhagic shock (Publication with Expression of Concern. See vol. 146, 2022) [J].

Guarini, S ;

Altavilla, D ;

Cainazzo, MM ;

Giuliani, D ;

Bigiani, A ;

Marini, H ;

Squadrito, G ;

Minutoli, L ;

Bertolini, A ;

Marini, R ;

Adarno, EB ;

Venuti, FS ;

Squadrito, F .

CIRCULATION, 2003, 107 (08) :1189-1194

[36] The relationship between heart rate variability and inflammatory markers in cardiovascular diseases [J].

Haensel, Alexander ;

Mills, Paul J. ;

Nelesen, Richard A. ;

Ziegler, Michael G. ;

Dimsdale, Joel E. .

PSYCHONEUROENDOCRINOLOGY, 2008, 33 (10) :1305-1312

[37] Stimulation of α7 nicotinic acetylcholine receptor inhibits CD14 and the toll-like receptor 4 expression in human monocytes [J].

Hamano, Ryosuke ;

Takahashi, Hideo Kohka ;

Iwagaki, Hiromi ;

Yoshino, Tadashi ;

Nishibori, Masahiro ;

Tanaka, Noriaki .

SHOCK, 2006, 26 (04) :358-364

[38]

Hansen MK, 2001, AM J PHYSIOL-REG I, V280, pR929

[39] The immune response in atherosclerosis: a double-edged sword [J].

Hansson, Goran K. ;

Libby, Peter .

NATURE REVIEWS IMMUNOLOGY, 2006, 6 (07) :508-519

[40] Cardiac autonomic changes associated with fish oil vs soy oil supplementation in the elderly [J].

Holguin, F ;

Téllez-Rojo, MM ;

Lazo, M ;

Mannino, D ;

Schwartz, J ;

Hernández, M ;

Romieu, I .

CHEST, 2005, 127 (04) :1102-1107

← 1 2 3 4 5 6 7 8 9 10 →