Reflex control of immunity

被引：793
作者：
Tracey, Kevin J. [1 ]
机构：
[1] Feinstein Inst Med Res, Manhasset, NY 11030 USA
来源：
NATURE REVIEWS IMMUNOLOGY | 2009年 / 9卷 / 06期
基金：
美国国家卫生研究院;
关键词：
HEART-RATE-VARIABILITY; CHOLINERGIC ANTIINFLAMMATORY PATHWAY; TUMOR-NECROSIS-FACTOR; NICOTINIC ACETYLCHOLINE-RECEPTORS; VAGUS NERVE-STIMULATION; COLLAGEN-INDUCED ARTHRITIS; SYSTEMIC INFLAMMATORY RESPONSE; C-REACTIVE PROTEIN; FACTOR-ALPHA; KAPPA-B;
D O I：
10.1038/nri2566
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Inflammation can cause damage and even death. What controls this primitive and potentially lethal innate immune response to injury and infection? Molecular and neurophysiological studies during the past decade have revealed a pivotal answer: immunity is coordinated by neural circuits that operate reflexively. The afferent arc of the reflex consists of nerves that sense injury and infection. This activates efferent neural circuits, including the cholinergic anti-inflammatory pathway, that modulate immune responses and the progression of inflammatory diseases. It might be possible to develop therapeutics that target neural networks for the treatment of inflammatory disorders.
引用
收藏
页码：418 / 428
页数：11
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