HISTOMORPHOLOGIC AND RESPIRATORY ASPECTS OF ACUTE LUNG INJURY IN RATS INDUCED BY EXPERIMENTAL SEPSIS AND UNDER PENTOXIFYLLINE TREATMENT

被引：2

作者：

Souza de Oliveira, Wagner Rogerio ^{[1
]}

Cavassani, Samia Santos ^{[1
]}

Maganhin, Carla Cristina ^{[1
]}

Ferraz Carbonel, Adriana Aparecida ^{[1
]}

Simoes, Manuel Jesus ^{[1
]}

Simoes, Ricardo Santos ^{[1
]}

Campos Junqueira, Virginia Berlanga

de Oliveira-Junior, Itamar Souza ^{[1
]}

机构：

[1] Univ Fed Sao Paulo, Escola Paulista Med, Sao Paulo, Brazil

来源：

REVISTA DA ASSOCIACAO MEDICA BRASILEIRA | 2009年 / 55卷 / 02期

关键词：

Sepsis; Acute lung injury; Mechanical ventilation; Cytokine; Pentoxifylline; PRESSURE-LIMITED VENTILATION; DISTRESS-SYNDROME; PERMISSIVE HYPERCAPNIA; SEPTIC SHOCK; TIDAL VOLUME; MORTALITY; MODEL; INFLAMMATION; MECHANISMS; STRATEGY;

D O I：

10.1590/S0104-42302009000200013

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

HISTOMORPHOLOGIC AND RESPIRATORY ASPECTS OF ACUTE LUNG INJURY IN RATS INDUCED BY EXPERIMENTAL SEPSIS AND UNDER PENTOXIFYLLINE TREATMENT OBJECTIVE. Respiratory repercussion on acute lung injury in a model of induced sepsis intraperitoneally. METHODS. Fifteen animals taken at random were submitted to adult male Wistar rats. The rats were randomly divided into 3 groups (n = 15): Group C - control group received only mechanical ventilation; Group S - rats received live Escherichia coli (E. coli) intraperitoneally (septic) and after 6 hours they were treated with normal saline infusion and ventilated with a low tidal volume. Group S+PIX - rats received live Escherichia coli intraperitoneally (septic) and after 6 hours they were treated with pentoxifylline (PTX) infusion and ventilated with a low tidal volume. All animals were ventilated during 180 minutes. We analyzed the arterial blood gases, gravimetric indices and histomorphometric analysis. RESULTS. Blood gases, wet to dry ratios, and total protein concentrations in the bronchoalveolar lavage were analyzed in all experimental groups. In the end of the experiment the partial pressure of oxygen was higher in the GS+PIX ( 460,0 + 38,2 mmHg) compared with GS (336,0 +/- 14,6 mmHg). Pentoxifylline with low tidal volume attenuated significantly total protein in the bronchoalveolar lavage. The septal diameter was significantly reduced in the group GS compared with group GS+PTX (P < 0,05). CONCLUSIONS. The pentoxifylline ameliorated the oxygenation and decreased the deleterious effects of sepsis in the associated mechanical ventilation. [Rev Assoc Med Bras 2009; 55( 2): 127-31]

引用

页码：127 / 131

页数：5

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