Palladium-Catalyzed Phosphorylation of Aryl Mesylates and Tosylates

被引：98
|
作者：
Fu, Wai Chung
So, Chau Ming
Kwong, Fuk Yee [1 ]
机构：
[1] Hong Kong Polytech Univ, State Key Lab Chirosci, Kowloon, Hong Kong, Peoples R China
来源：
ORGANIC LETTERS | 2015年 / 17卷 / 23期
关键词：
CROSS-COUPLING REACTIONS; P BOND FORMATION; ARYLBORONIC ACIDS; ALPHA-ARYLATION; INHIBITORS; PHOSPHINE; AMINATION; DIPHENYLPHOSPHINE; COMPLEXES; CHLORIDES;
D O I：
10.1021/acs.orglett.5b03104
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The first general palladium catalyst for the phosphorylation of aryl mesylates and tosylates is reported. The newly developed system exhibits excellent functional group compatibility. For instance, free amino, keto, ester, and amido groups, as well as heterocycles, remain intact during the course of reaction. The mesylated derivatives of biologically active compounds such as 17 beta-estradiol and 6-hydroxyflavone are also shown to be applicable substrates. A one-pot phosphorylation-amination sequence is described for the facile synthesis of potential phannacophores.
引用
收藏
页码：5906 / 5909
页数：4
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