Synthesis and antifungal bioactivities of 3-alkylquinazolin-4-one derivatives

被引：50

作者：

Ouyang, Guiping ^{[1
]}

Zhang, Peiquan ^{[1
]}

Xu, Gangfang ^{[1
]}

Song, Baoan ^{[1
]}

Yang, Song ^{[1
]}

An, Linhong ^{[1
]}

Xue, Wei ^{[1
]}

Hu, Deyu ^{[1
]}

Lu, Ping ^{[1
]}

Chen, Zhuo ^{[1
]}

机构：

[1] Guizhou Univ, Ctr Res & Dev Fine Chem, Key Lab Green Pesticide & Agr Bioengn, Minist Educ, Guiyang 550025, Peoples R China

来源：

MOLECULES | 2006年 / 11卷 / 06期

关键词：

quinazolinone; phase transfer catalyst; synthesis; antifungal activity;

D O I：

10.3390/11060383

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A simple, efficient, and general method has been developed for the synthesis of various 3-alkylquinazolin-4-one derivatives from quinazolin-4-one treated with alkyl bromides under phase transfer catalysis condition. The structures of the compounds were characterized by elemental analysis, IR, H-1-NMR and C-13-NMR spectra. Title compound 6-bromo-3-propylquinazolin-4-one (3h) was found to possess good antifungal activity.

引用

页码：383 / 392

页数：10

共 50 条

[41] Studies on the synthesis and bioactivities of substituted dihydropyrazole derivatives
Liu, TL
Yu, SL
Yu, AM
CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE, 1998, 19 (02): : 232 - 236
[42] Synthesis and Antibacterial and Antifungal Activity of New Thieno[2,3-d]Pyrimidin-4(3H)-One Derivatives
B. Kahveci
İ. S. Doğan
E. Menteşe
H. E. Sellitepe
D. Kart
Pharmaceutical Chemistry Journal, 2020, 54 : 647 - 653
[43] Synthesis of Novel Thiazolidine-4-One Derivatives, Their Cytotoxicity, Antifungal Properties, Molecular Docking and Molecular Dynamics
Kosurkar, U. B.
Mamilla, J.
Dadmal, T. L.
Choudante, P. C.
Mali, S. N.
Misra, S.
Kumbhare, R. M.
RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY, 2023, 49 (02) : 314 - 323
[44] Synthesis and Bioactivities of Novel 1,3,4-Thiadiazole Derivatives of Glucosides
Chen, Meihang
Zhang, Xun
Lu, Daowang
Luo, Hairong
Zhou, Zengyan
Qin, Xufeng
Wu, Wenneng
Zhang, Guoping
FRONTIERS IN CHEMISTRY, 2021, 9
[45] Antifungal agents. Part 5: Synthesis and antifungal activities of aminoguanidine derivatives of N-arylsulfonyl-3-acylindoles
Xu, Hui
Wang, Yang-Yang
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2010, 20 (24) : 7274 - 7277
[46] Convenient One-Pot Synthesis of Chromone Derivatives and Their Antifungal and Antibacterial Evaluation
Ghani, Sherif B. Abdel
Mugisha, Patrick J.
Wilcox, Juliet C.
Gado, Emad A. M.
Medu, Erere O.
Lamb, Andrew J.
Brown, Richard C. D.
SYNTHETIC COMMUNICATIONS, 2013, 43 (11) : 1549 - 1556
[47] Synthesis of 1, 2, 4-triazole benzoyl arylamine derivatives and their high antifungal activities
Cheng, Yi-Nan
Jiang, Zhen-Hua
Sun, Lian-Sheng
Su, Zi-Yang
Zhang, Meng-Meng
Li, Hong-Lian
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020, 200
[48] Synthesis and Antifungal Activities of Some Novel Pyrimidine Derivatives
Sun, Li
Wu, Jie
Zhang, Lingzi
Luo, Min
Sun, Dequn
MOLECULES, 2011, 16 (07): : 5618 - 5628
[49] Synthesis and Antifungal Activity of 2-Thiazoleacrylonitrile Derivatives
Weng, Jian-Quan
Yu, Zhi-Qin
Liu, Xing-Hai
Tong, Guo-Tong
ASIAN JOURNAL OF CHEMISTRY, 2012, 24 (05) : 2249 - 2252
[50] Synthesis and antifungal bioactivity of 6-bromo-4-alkylthioquinazoline derivatives
Ma, Yao
Liu, Fang
Yan, Kai
Song, Bao-An
Yang, Song
Hu, De-Yu
Jin, Lin-Hong
Xue, Wei
CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2008, 28 (07) : 1268 - 1272

← 1 2 3 4 5 →