Synthesis and antifungal bioactivities of 3-alkylquinazolin-4-one derivatives

被引：50

作者：

Ouyang, Guiping ^{[1
]}

Zhang, Peiquan ^{[1
]}

Xu, Gangfang ^{[1
]}

Song, Baoan ^{[1
]}

Yang, Song ^{[1
]}

An, Linhong ^{[1
]}

Xue, Wei ^{[1
]}

Hu, Deyu ^{[1
]}

Lu, Ping ^{[1
]}

Chen, Zhuo ^{[1
]}

机构：

[1] Guizhou Univ, Ctr Res & Dev Fine Chem, Key Lab Green Pesticide & Agr Bioengn, Minist Educ, Guiyang 550025, Peoples R China

来源：

MOLECULES | 2006年 / 11卷 / 06期

关键词：

quinazolinone; phase transfer catalyst; synthesis; antifungal activity;

D O I：

10.3390/11060383

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A simple, efficient, and general method has been developed for the synthesis of various 3-alkylquinazolin-4-one derivatives from quinazolin-4-one treated with alkyl bromides under phase transfer catalysis condition. The structures of the compounds were characterized by elemental analysis, IR, H-1-NMR and C-13-NMR spectra. Title compound 6-bromo-3-propylquinazolin-4-one (3h) was found to possess good antifungal activity.

引用

页码：383 / 392

页数：10

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