Synthesis and antifungal bioactivities of 3-alkylquinazolin-4-one derivatives

被引：50

作者：

Ouyang, Guiping ^{[1
]}

Zhang, Peiquan ^{[1
]}

Xu, Gangfang ^{[1
]}

Song, Baoan ^{[1
]}

Yang, Song ^{[1
]}

An, Linhong ^{[1
]}

Xue, Wei ^{[1
]}

Hu, Deyu ^{[1
]}

Lu, Ping ^{[1
]}

Chen, Zhuo ^{[1
]}

机构：

[1] Guizhou Univ, Ctr Res & Dev Fine Chem, Key Lab Green Pesticide & Agr Bioengn, Minist Educ, Guiyang 550025, Peoples R China

来源：

MOLECULES | 2006年 / 11卷 / 06期

关键词：

quinazolinone; phase transfer catalyst; synthesis; antifungal activity;

D O I：

10.3390/11060383

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A simple, efficient, and general method has been developed for the synthesis of various 3-alkylquinazolin-4-one derivatives from quinazolin-4-one treated with alkyl bromides under phase transfer catalysis condition. The structures of the compounds were characterized by elemental analysis, IR, H-1-NMR and C-13-NMR spectra. Title compound 6-bromo-3-propylquinazolin-4-one (3h) was found to possess good antifungal activity.

引用

页码：383 / 392

页数：10

共 50 条

[21] Synthesis and in vitro antifungal activities of new 3-substituted benzopyrone derivatives
Lv, Zhiliang
Sheng, Chunquan
Zhang, Yikai
Wang, Tiantian
Feng, Jilu
Sun, Hailing
Zhong, Hanyu
Zhang, Mingfeng
Chen, Huan
Li, Ke
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2010, 20 (23) : 7106 - 7109
[22] Design, synthesis and antifungal activity evaluation of coumarin-3-carboxamide derivatives
Yu, Xiang
Teng, Peng
Zhang, Ya-Ling
Xu, Zhao-Jun
Zhang, Ming-Zhi
Zhang, Wei-Hua
FITOTERAPIA, 2018, 127 : 387 - 395
[23] Synthesis of methylquinazolin-4(3H)-one derivatives
KalinowskaTorz, J
Skwarski, D
Sobiak, S
Piechocki, S
POLISH JOURNAL OF CHEMISTRY, 1997, 71 (01) : 57 - 62
[24] Synthesis, Characterization and Antifungal Evaluation of Novel Pyridazin-3(2H)-One Derivatives
Hamed, Mai Y.
Aly, Aly Fahmy
Abdullah, Nashwa Hamed
Ismail, Mahmoud F.
POLYCYCLIC AROMATIC COMPOUNDS, 2023, 43 (03) : 2356 - 2375
[25] Design, synthesis, antifungal activity, and 3D-QSAR of coumarin derivatives
Wei, Yan
Peng, Wei
Wang, Dong
Hao, Shuang-Hong
Li, Wen-Wen
Ding, Fei
JOURNAL OF PESTICIDE SCIENCE, 2018, 43 (1-2) : 88 - 95
[26] Synthesis of pyrazole-4-carbaldehyde derivatives for their antifungal activity
Vadiyala Naveen Reddy
Lingala Yamini
Yerrabelly Jayaprakash Rao
Chitneni Prasad Rao
Medicinal Chemistry Research, 2017, 26 : 1664 - 1674
[27] Synthesis and Antifungal Activity of Cuminic Acid Derivatives
Yang, Jian
Gao, Yang
Liu, Hui
Tang, Xiaorong
CHEMISTRY OF NATURAL COMPOUNDS, 2017, 53 (06) : 1112 - 1116
[28] Synthesis of pyrazole-4-carbaldehyde derivatives for their antifungal activity
Reddy, Vadiyala Naveen
Yamini, Lingala
Rao, Yerrabelly Jayaprakash
Rao, Chitneni Prasad
MEDICINAL CHEMISTRY RESEARCH, 2017, 26 (08) : 1664 - 1674
[29] 4-Methylumbelliferone fused oxazole thioether derivatives: synthesis, characterization and antifungal activities
Xu, Hong-Lei
Wei, Yan
Hao, Shuanghong
NATURAL PRODUCT RESEARCH, 2022, 36 (03) : 707 - 713
[30] Synthesis and antifungal properties of (4-tolyloxy)-pyrimidyl-α-aminophosphonates chitosan derivatives
Qin, Yukun
Xing, Ronge
Liu, Song
Yu, Huahua
Li, Kecheng
Hu, Linfeng
Li, Pengcheng
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2014, 63 : 83 - 91

← 1 2 3 4 5 →