Aigialomycins and related polyketide metabolites from the mangrove fungus Aigialus parvus BCC 5311

被引：84

作者：

Isaka, Masahiko ^{[1
]}

Yangchum, Arunrat ^{[1
]}

Intamas, Sutichai ^{[1
]}

Kocharin, Kanokarn ^{[1
]}

Jones, E. B. Gareth ^{[1
]}

Kongsaeree, Palangpon ^{[2
,3
]}

Prabpai, Samran ^{[2
]}

机构：

[1] BIOTEC, Natl Ctr Genet Engn & Biotechnol, Klongluang 12120, Pathumthani, Thailand

[2] Mahidol Univ, Fac Sci, Dept Chem, Bangkok 10400, Thailand

[3] Mahidol Univ, Fac Sci, Ctr Excellence Prot Struct & Funct, Bangkok 10400, Thailand

来源：

TETRAHEDRON | 2009年 / 65卷 / 22期

关键词：

Aigialus parvus; Resorcylic acid lactone; Marine fungi; Aigialomycin; Aigialospirol; ENANTIOSELECTIVE TOTAL-SYNTHESIS; RESORCYLIC ACID LACTONES; HYPOTHEMYCIN; KINASE; STEREOCHEMISTRY; MACROLIDES; MEK;

D O I：

10.1016/j.tet.2009.03.050

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Reinvestigation of the secondary metabolites from the marine mangrove fungus Aigialus parvus BCC 5311 led to the isolation of six new nonaketide metabolites, aigialomycins F (4) and G (5a/5b), 7',8'-dihydroaigialospirol (7), 4'-deoxy-7',8'-dihydroaigialospirol (8), and rearranged macrolides 9 and 10, along with six previously described compounds, hypothemycin (1), aigialomycins A (2) and B (3), aigialospirol (6), 4-O-demethylhypothemycin (11), and aigialone (12). The structures of the new compounds were elucidated by analyses of the NMR spectroscopic and mass spectrometry data in combination with chemical means. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：4396 / 4403

页数：8

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