The Intestine Harbors Functionally Distinct Homeostatic Tissue-Resident and Inflammatory Th17 Cells

被引：260

作者：

Omenetti, Sara ^{[1
]}

Bussi, Claudio ^{[1
]}

Metidji, Amina ^{[1
,3
]}

Iseppon, Andrea ^{[1
]}

Lee, Sunjae ^{[1
,2
]}

Tolaini, Mauro ^{[1
]}

Li, Ying ^{[1
]}

Kelly, Gavin ^{[1
]}

Chakravarty, Probir ^{[1
]}

Shoaie, Saeed ^{[1
,2
]}

Gutierrez, Maximiliano G. ^{[1
]}

Stockinger, Brigitta ^{[1
]}

机构：

[1] Francis Crick Inst, 1 Midland Rd, London NW1 1AT, England

[2] Kings Coll London, Ctr Host Microbiome Interact, Fac Dent Oral & Craniofacial Sci, London SE1 9RT, England

[3] CRAPC, Ctr Rech Sci & Tech Analyses Physicochim, Algiers, Algeria

来源：

IMMUNITY | 2019年 / 51卷 / 01期

基金：

英国惠康基金; 英国医学研究理事会; 英国工程与自然科学研究理事会;

关键词：

SEGMENTED FILAMENTOUS BACTERIA; PATHOGENIC T(H)17 CELLS; LYMPHOID-TISSUES; GUT MICROBIOTA; T-CELLS; INDUCTION; MATURATION; RECEPTOR; DRIVES; FATE;

D O I：

10.1016/j.immuni.2019.05.004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

T helper 17 (Th17) cells are pathogenic inmany inflammatory diseases, but also support the integrity of the intestinal barrier in a non-inflammatory manner. It is unclear what distinguishes inflammatory Th17 cells elicited by pathogens and tissue-resident homeostatic Th17 cells elicited by commensals. Here, we compared the characteristics of Th17 cells differentiating in response to commensal bacteria (SFB) to those differentiating in response to a pathogen (Citrobacter rodentium). Homeostatic Th17 cells exhibited little plasticity towards expression of inflammatory cytokines, were characterized by a metabolism typical of quiescent or memory T cells, and did not participate in inflammatory processes. In contrast, infection-induced Th17 cells showed extensive plasticity towards pro-inflammatory cytokines, disseminated widely into the periphery, and engaged aerobic glycolysis in addition to oxidative phosphorylation typical for inflammatory effector cells. These findings will help ensure that future therapies directed against inflammatory Th17 cells do not inadvertently damage the resident gut population.

引用

页码：77 / +

页数：19

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