Body mass index and cancer incidence: the FINRISK study

被引：35

作者：

Song, Xin ^{[1
,2
]}

Pukkala, Eero ^{[3
,4
]}

Dyba, Tadeusz ^{[3
]}

Tuomilehto, Jaakko ^{[2
,5
,6
]}

Moltchanov, Vladislav ^{[1
,2
]}

Mannisto, Satu ^{[2
]}

Jousilahti, Pekka ^{[2
]}

Qiao, Qing ^{[1
,7
]}

机构：

[1] Univ Helsinki, Dept Publ Hlth, Hjelt Inst, Helsinki 00014, Finland

[2] Natl Inst Hlth & Welf, Dept Chron Dis Prevent, Helsinki, Finland

[3] Finnish Canc Registry, Inst Stat & Epidemiol Canc Res, FIN-00170 Helsinki, Finland

[4] Univ Tampere, Sch Hlth Sci, FIN-33101 Tampere, Finland

[5] Danube Univ Krems, Ctr Vasc Prevent, Krems, Austria

[6] King Abdulaziz Univ, Jeddah 21413, Saudi Arabia

[7] R&D AstraZeneca AB, Molndal, Sweden

来源：

EUROPEAN JOURNAL OF EPIDEMIOLOGY | 2014年 / 29卷 / 07期

关键词：

Body mass index; Cancer incidence; POSTMENOPAUSAL BREAST-CANCER; MILLION NORWEGIAN MEN; RENAL-CELL CARCINOMA; PHYSICAL-ACTIVITY; PROSTATE-CANCER; WEIGHT CHANGE; COLORECTAL-CANCER; PANCREATIC-CANCER; LUNG-CANCER; GALLBLADDER CANCER;

D O I：

10.1007/s10654-014-9934-z

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

The relation between body mass index (BMI) and risk of cancer incidence is controversial. Cancer incidence during 1972-2008 in relation to BMI was investigated in a prospective cohort of 54,725 Finns aged 24-74 years and free of cancer at enrollment. Over a mean follow-up of 20.6 years, 8,429 (15.4 %) incident cancers were recorded, 4,208 (49.9 %) from men. Both parametric and nonparametric approaches were used to evaluate the shape of the relationship between BMI and incidence of cancer. BMI had a linear positive association with incidence of cancers of the colon, liver, kidney, bladder and all sites combined in men, and of cancers of the stomach, colon, gallbladder and ovary in women, an inverse association with incidence of cancers of the lung in men and the lung and breast in women, a J-shaped association with incidence of all cancers combined in women. High BMI in women was associated with an increased overall cancer risk in never smokers but a reduced risk in smokers. Elevated BMI was associated with an increased risk of incidence of cancers of certain sites.

引用

页码：477 / 487

页数：11

共 77 条

[11] Overweight, obesity and cancer: Epidemiological evidence and proposed mechanisms [J].