Synthesis, characterization and biological evaluation of 4-oxo-thiazolidine compounds

被引：5

作者：

Godhani, Dinesh R. ^{[1
]}

Jogel, Anand A. ^{[1
]}

Dobariya, Purvesh B. ^{[1
]}

Sanghani, Anil M. ^{[2
]}

机构：

[1] Maharaja Krishnakumarsinhji Bhavnagar Univ, Dept Chem, DST FIST Sponsored, Mahatma Gandhi Campus, Bhavnagar 364022, Gujarat, India

[2] Sir PP Inst Sci, Dept Chem, Bhavnagar 364002, Gujarat, India

来源：

JOURNAL OF SAUDI CHEMICAL SOCIETY | 2016年 / 20卷

关键词：

4-Oxo-thiazolidine; Antibacterial activity; Antifungal activity; Antitubercular activity; 4-THIAZOLIDINONES; ANTIBACTERIAL; DERIVATIVES; THIAZOLIDINONES; ANTIFUNGAL; INHIBITORS; ACID;

D O I：

10.1016/j.jscs.2013.03.002

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A series of compounds 4-oxo-thiazolidine derivatives AJ5(a-j) were synthesized by condensation reactions. The structure of synthesized compounds was characterized by IR, H-1 NMR, C-13 NMR and mass spectroscopy. The present paper deals with newly synthesized thiazolidine compounds AJ5(a)-AJ5(j) that were screened for their antimicrobial activity against different strains of bacteria and fungi using serial broth dilution method (Mueller-Hinton broth dilution method). In vitro antitubercular activity of compounds AJ5(a-j) was carried out against Mycobacterium tuberculosis H(37)Rv. Compounds AJ5(a), AJ5(d), AJ5(e), AJ5(f) and AJ5(g) were found most active against selected bacterial strains (MIC = 62.5 mu g/mL) and compounds AJ5(a-j) were found moderately active against M. tuberculosis. (C) 2013 Production and hosting by Elsevier B.V. on behalf of King Saud University.

引用

页码：S523 / S535

页数：13

共 30 条

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