Antidepressant Treatment with Venlafaxine and Mirtazapine: no Effect on Serum Concentration of Vascular Endothelial Growth Factor (VEGF)

被引：4
作者：
Deuschle, M. [1 ]
Gilles, M. [1 ]
Scharnholz, B. [1 ]
Kahl, K. G. [2 ]
机构：
[1] Heidelberg Univ, Fac Med Mannheim, Cent Inst Mental Hlth, Mannheim, Germany
[2] Hannover Med Sch, Dept Psychiat Social Psychiat & Psychotherapy, Hannover, Germany
来源：
PHARMACOPSYCHIATRY | 2015年 / 48卷 / 07期
关键词：
vascular endothelial growth factor (VEGF); brain-derived neurotrophic factor (BDNF); depression; remission; antidepressant; NEUROTROPHIC FACTOR; DEPRESSION;
D O I：
10.1055/s-0035-1555849
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Introduction: Depression, stress and antidepressant treatment have been found to modulate the expression of growth factors. Methods: We studied depressed patients receiving randomized treatment with venlafaxine or mirtazapine for 28 days. Results: There was no significant difference between baseline VEGF concentrations in depressed patients compared to healthy controls. We found no significant effect of antidepressant treatment on serum VEGF. Discussion: In contrast to serum BDNF, VEGF may not be a suitable biomarker for effects of antidepressant treatment with venlafaxine or mirtazapine.
引用
收藏
页码：292 / 293
页数：2
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