Novel cardiovascular biomarkers in women with a history of early preeclampsia

被引:25
作者
Drost, Jose T. [1 ]
Maas, Angela H. E. M. [2 ]
Holewijn, Suzanne [3 ]
Joosten, Leo A. B. [3 ]
van Eyck, Jim [4 ]
van der Schouw, Yvonne T. [5 ]
de Graaf, Jacqueline [3 ]
机构
[1] Isala Klin, Dept Cardiol, Zwolle, Netherlands
[2] Radboud Univ Nijmegen, Med Ctr, Dept Cardiol, NL-6500 HB Nijmegen, Netherlands
[3] Radboud Univ Nijmegen, Med Ctr, Dept Internal Med, Div Vasc Med, NL-6500 HB Nijmegen, Netherlands
[4] Isala Klin, Dept Obstet & Gynaecol, Zwolle, Netherlands
[5] Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands
关键词
Preeclampsia; Cardiovascular disease; Atherosclerosis; Endothelial function; Biomarker; PLASMA PROTEIN-A; DENSITY-LIPOPROTEIN CHOLESTEROL; TYPE-2; DIABETES-MELLITUS; RISK-FACTORS; INSULIN-RESISTANCE; APOLIPOPROTEIN-B; LATER LIFE; PREGNANCY; DISEASE; METAANALYSIS;
D O I
10.1016/j.atherosclerosis.2014.09.009
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective: Women with a history of preeclampsia are at increased risk for future cardiovascular disease. Determination of cardiovascular biomarkers may be useful to understand the pathophysiological mechanism of cardiovascular disease development in these women. Methods: We performed an analysis in the Preeclampsia Risk EValuation in FEMales study, a retrospective cohort consisting of 339 women with a history of early preeclampsia and 332 women after normotensive pregnancy. Women attended a follow up visit ten years after the index pregnancy. A subset of 8 different cardiovascular biomarkers was investigated, reflecting inflammatory, metabolic, thrombotic and endothelial function markers. Associations between PE and these novel biomarkers were analyzed by linear regression analysis and adjusted for traditional cardiovascular risk factors. Results: Mean age of 671 women of the PREVFEM cohort was 39 years and women were on average 10 years post index pregnancy. Women post preeclampsia had significantly higher levels of SE selectin (adjusted difference 4.55, 99% CI 0.37; 8.74) and PAPPA (adjusted difference 19.08; 99% CI 13.18; 24.99), whereas ApoB (adjusted difference -0.23 99% CI -0.32; -0.14) was inversely associated with preeclampsia, compared to women with a previous normotensive pregnancy. Adiponectin, leptin, sICAM-1, sVCAM-1 and PAI-1 were not different between both groups. Conclusion: We demonstrated an independent association of preeclampsia with SE selectin and PAPPA (markers of vascular dysfunction), which may contribute to future cardiovascular events in women post preeclampsia. However, ApoB (an apolipoprotein) was significantly lower and could point at a protective mechanism in our PE study women. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:117 / 122
页数:6
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