Is glutamine depletion needed in ALL disease?

被引：8

作者：

Avramis, Vassilios I. ^{[1
,2
]}

机构：

[1] Keck Sch Med, Los Angeles, CA 90033 USA

[2] Childrens Hosp Los Angeles, Los Angeles, CA USA

来源：

BLOOD | 2014年 / 123卷 / 23期

关键词：

L-ASPARAGINASE; LEUKEMIA; RESISTANCE;

D O I：

10.1182/blood-2014-04-565523

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In this issue of Blood, Chan et al report on an innovative study using molecular dynamics and mapping to identify and produce a promising bioengineered clone of Escherichia coli asparaginase (ASNase), mutated at Q59L position (Gln59Leu). The Q59L variant ASNase has undetectable glutaminase coactivity, while retaining its ASNase activity © 2014 by The American Society of Hematology.

引用

页码：3532 / 3533

页数：2

共 10 条

[1]

Avramis VI, 2012, ANTICANCER RES, V32, P2423

[2] The eIF2 Kinase GCN2 Is Essential for the Murine Immune System to Adapt to Amino Acid Deprivation by Asparaginase [J].

Bunpo, Piyawan ;

Cundiff, Judy K. ;

Reinert, Rachel B. ;

Wek, Ronald C. ;

Aldrich, Carla J. ;

Anthony, Tracy G. .

JOURNAL OF NUTRITION, 2010, 140 (11) :2020-2027

[3] The glutaminase activity of L-asparaginase is not required for anticancer activity against ASNS-negative cells [J].

Chan, Wai Kin ;

Lorenzi, Philip L. ;

Anishkin, Andriy ;

Purwaha, Preeti ;

Rogers, David M. ;

Sukharev, Sergei ;

Rempe, Susan B. ;

Weinstein, John N. .

BLOOD, 2014, 123 (23) :3596-3606

[4] Expanding Targets for a Metabolic Therapy of Cancer: L-Asparaginase [J].

Covini, Daniele ;

Tardito, Saverio ;

Bussolati, Ovidio ;

Chiarelli, Laurent R. ;

Pasquetto, Maria V. ;

Digilio, Rita ;

Valentini, Giovanna ;

Scotti, Claudia .

RECENT PATENTS ON ANTI-CANCER DRUG DISCOVERY, 2012, 7 (01) :4-13

[5] Adipocytes Cause Leukemia Cell Resistance to L-Asparaginase via Release of Glutamine [J].

Ehsanipour, Ehsan A. ;

Sheng, Xia ;

Behan, James W. ;

Wang, Xingchao ;

Butturini, Anna ;

Avramis, Vassilios I. ;

Mittelman, Steven D. .

CANCER RESEARCH, 2013, 73 (10) :2998-3006

[6]

Fine BM, 2005, CANCER RES, V65, P291

[7] Unraveling the Enigmatic Mechanism of L-Asparaginase II with QM/QM Calculations [J].

Gesto, Diana S. ;

Cerqueira, Nuno M. F. S. A. ;

Fernandes, Pedro A. ;

Ramos, Maria J. .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2013, 135 (19) :7146-7158

[8] A covalently bound catalytic intermediate in Escherichia coli asparaginase: Crystal structure of a Thr-89-val mutant [J].

Palm, GJ ;

Lubkowski, J ;

Derst, C ;

Schleper, S ;

Rohm, KH ;

Wlodawer, A .

FEBS LETTERS, 1996, 390 (02) :211-216

[9] A dyad of lymphoblastic lysosomal cysteine proteases degrades the antileukemic drug L-asparaginase [J].

Patel, Naina ;

Krishnan, Shekhar ;

Offman, Marc N. ;

Krol, Marcin ;

Moss, Catherine X. ;

Leighton, Carly ;

van Delft, Frederik W. ;

Holland, Mark ;

Liu, JiZhong ;

Alexander, Seema ;

Dempsey, Clare ;

Ariffin, Hany ;

Essink, Monika ;

Eden, Tim O. B. ;

Watts, Colin ;

Bates, Paul A. ;

Saha, Vaskar .

JOURNAL OF CLINICAL INVESTIGATION, 2009, 119 (07) :1964-1973

[10] Inhibiting glutamine uptake represents an attractive new strategy for treating acute myeloid leukemia [J].

Willems, Lise ;

Jacque, Nathalie ;

Jacquel, Arnaud ;

Neveux, Nathalie ;

Maciel, Thiago Trovati ;

Lambert, Mireille ;

Schmitt, Alain ;

Poulain, Laury ;

Green, Alexa S. ;

Uzunov, Madalina ;

Kosmider, Olivier ;

Radford-Weiss, Isabelle ;

Moura, Ivan Cruz ;

Auberger, Patrick ;

Ifrah, Norbert ;

Bardet, Valerie ;

Chapuis, Nicolas ;

Lacombe, Catherine ;

Mayeux, Patrick ;

Tamburini, Jerome ;

Bouscary, Didier .

BLOOD, 2013, 122 (20) :3521-3532

← 1 →