Is glutamine depletion needed in ALL disease?

被引：8
作者：
Avramis, Vassilios I. [1 ,2 ]
机构：
[1] Keck Sch Med, Los Angeles, CA 90033 USA
[2] Childrens Hosp Los Angeles, Los Angeles, CA USA
来源：
BLOOD | 2014年 / 123卷 / 23期
关键词：
L-ASPARAGINASE; LEUKEMIA; RESISTANCE;
D O I：
10.1182/blood-2014-04-565523
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
In this issue of Blood, Chan et al report on an innovative study using molecular dynamics and mapping to identify and produce a promising bioengineered clone of Escherichia coli asparaginase (ASNase), mutated at Q59L position (Gln59Leu). The Q59L variant ASNase has undetectable glutaminase coactivity, while retaining its ASNase activity © 2014 by The American Society of Hematology.
引用
收藏
页码：3532 / 3533
页数：2
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