A New Phenolic Component from Triticum aestivum Sprouts and its Effects on LPS-Stimulated Production of Nitric oxide and TNF-α in RAW 264.7 Cells

被引：30

作者：

Bui Thi Thuy Luyen ^{[1
]}

Bui Huu Tai ^{[1
,2
]}

Nguyen Phuong Thao ^{[1
,2
]}

Cha, Ji Yun ^{[3
,4
]}

Lee, Young Mi ^{[3
,4
]}

Kim, Young Ho ^{[1
]}

机构：

[1] Chungnam Natl Univ, Coll Pharm, Taejon 305764, South Korea

[2] Vietnam Acad Sci & Technol, Inst Marine Biochem, Hanoi, Vietnam

[3] Wonkwang Univ, Coll Pharm, Dept Oriental Pharm, Iksan 570749, Jonbuk, South Korea

[4] Wonkwang Oriental Med Res Inst, Iksan 570749, Jonbuk, South Korea

来源：

PHYTOTHERAPY RESEARCH | 2014年 / 28卷 / 07期

基金：

新加坡国家研究基金会;

关键词：

triticumoside; phenolic; Triticum aestivum; NO; TNF-alpha; anti-inflammation; CONSTITUENTS; INHIBITION; WHEATS; L;

D O I：

10.1002/ptr.5097

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

An unusual new phenolic component, triticumoside (1), and eight known compounds, isoorientin (2), isoscoparin (3), (2R)-2-O-beta-D-glucopyranosyloxy-4,7-dimethoxy-2H-1,4-benzoxazin-3(4H)-one (4), adenosine (5), beta-sitosterol (6), daucosterol (7), 6'-O-linolenoyl daucosterol (8), a-tocopherol (9), were isolated from Triticum aestivum sprouts. The hybrid structure of 1, which is a hybrid between a flavone and a polyoxygenated benzene, is rarely found in natural sources. In addition, the effects of these compounds on LPS-induced NO and TNF-alpha production in RAW 264.7 cells were evaluated. At a concentration of 2.0 mu M, compounds 2-4 significantly inhibited the production of both NO and TNF-alpha. Compound 1 exhibited inhibitory activity on the secretion of TNF-alpha at concentrations as low as 2.0 mu M, but it did not reduce NO levels at any of the tested concentrations. Copyright (C) 2013 John Wiley & Sons, Ltd.

引用

页码：1064 / 1070

页数：7

共 23 条

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