The Search for Antiaging Interventions: From Elixirs to Fasting Regimens

被引：249

作者：

de Cabo, Rafael ^{[1
]}

Carmona-Gutierrez, Didac ^{[3
]}

Bernier, Michel ^{[1
]}

Hall, Michael N. ^{[2
]}

Madeo, Frank ^{[3
]}

机构：

[1] NIA, Translat Gerontol Branch, NIH, Baltimore, MD 21224 USA

[2] Univ Basel, CH-4056 Basel, Switzerland

[3] Graz Univ, Inst Mol Biosci, A-8010 Graz, Austria

来源：

CELL | 2014年 / 157卷 / 07期

基金：

奥地利科学基金会; 美国国家卫生研究院; 瑞士国家科学基金会;

关键词：

EXTENDS LIFE-SPAN; ALL-CAUSE MORTALITY; CALORIC RESTRICTION; SACCHAROMYCES-CEREVISIAE; OXIDATIVE-STRESS; CAENORHABDITIS-ELEGANS; INSULIN-RESISTANCE; PHYSICAL-ACTIVITY; RHESUS-MONKEYS; C-ELEGANS;

D O I：

10.1016/j.cell.2014.05.031

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The phenomenon of aging is an intrinsic feature of life. Accordingly, the possibility to manipulate it has fascinated humans likely since time immemorial. Recent evidence is shaping a picture where low caloric regimes and exercise may improve healthy senescence, and several pharmacological strategies have been suggested to counteract aging. Surprisingly, the most effective interventions proposed to date converge on only a few cellular processes, in particular nutrient signaling, mitochondrial efficiency, proteostasis, and autophagy. Here, we critically examine drugs and behaviors to which life- or healthspan-extending properties have been ascribed and discuss the underlying molecular mechanisms.

引用

页码：1515 / 1526

页数：12

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