Mitochondrial DNA repeats constrain the life span of mammals

被引：44

作者：

Samuels, DC ^{[1
]}

机构：

[1] Virginia Polytech Inst & State Univ, Virginia Bioinformat Inst, Blacksburg, VA 24061 USA

来源：

TRENDS IN GENETICS | 2004年 / 20卷 / 05期

关键词：

D O I：

10.1016/j.tig.2004.03.003

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Mitochondrial DNA deletions, which are often flanked by repeats, are found in elderly organisms of many species. In this article, I describe the analysis of the mitochondrial genomes of 61 mammalian species and show that the number of the longer repeats constrains the typical life span. I also show that the number of repeats that occur in randomly shuffled sequences is a rough lower limit to the number in the actual sequences. These two constraints imply a maximum life expectancy for mammals of 80-100 years.

引用

页码：226 / 229

页数：4

共 35 条

[1] DELETERIOUS MITOCHONDRIAL-DNA MUTATIONS ACCUMULATE IN AGING HUMAN TISSUES [J].

ARNHEIM, N ;

CORTOPASSI, G .

MUTATION RESEARCH, 1992, 275 (3-6) :157-167

[2] Role of mitochondrial DNA in human aging [J].

Attardi, G .

MITOCHONDRION, 2002, 2 (1-2) :27-37

[3] Replicational model for DNA recombination between direct repeats [J].

Bi, X ;

Liu, LF .

JOURNAL OF MOLECULAR BIOLOGY, 1996, 256 (05) :849-858

[4] MULTIPLE DELETIONS IN MITOCHONDRIAL-DNA ARE PRESENT IN SENESCENT MOUSE-BRAIN [J].

BROSSAS, JY ;

BARREAU, E ;

COURTOIS, Y ;

TRETON, J .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1994, 202 (02) :654-659

[5] Mitochondrial genomes: anything goes [J].

Burger, G ;

Gray, MW ;

Lang, BF .

TRENDS IN GENETICS, 2003, 19 (12) :709-716

[6] Analysis of age-associated mitochondrial DNA deletion breakpoint regions from mice suggests a novel model of deletion formation. [J].

Chung, SS ;

Eimon, PM ;

Weindruch, R ;

Aiken, JM .

AGE, 1996, 19 (04) :117-128

[7] Mitochondria in organismal aging and degeneration [J].

Cortopassi, GA ;

Wong, A .

BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, 1999, 1410 (02) :183-193

[8] DETECTION OF A SPECIFIC MITOCHONDRIAL-DNA DELETION IN TISSUES OF OLDER HUMANS [J].

CORTOPASSI, GA ;

ARNHEIM, N .

NUCLEIC ACIDS RESEARCH, 1990, 18 (23) :6927-6933

[9] Random intracellular drift explains the clonal expansion of mitochondrial DNA mutations with age [J].

Elson, JL ;

Samuels, DC ;

Turnbull, DM ;

Chinnery, PF .

AMERICAN JOURNAL OF HUMAN GENETICS, 2001, 68 (03) :802-806

[10] MITOCHONDRIAL-DNA COPY NUMBER AND MITOCHONDRIAL-DNA DELETION IN ADULT AND SENESCENT RATS [J].

GADALETA, MN ;

RAINALDI, G ;

LEZZA, AMS ;

MILELLA, F ;

FRACASSO, F ;

CANTATORE, P .

MUTATION RESEARCH, 1992, 275 (3-6) :181-193

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