Clinicopathological analysis of polyploid diffuse large B-cell lymphoma

被引：9

作者：

Shimono, Joji ^{[1
,2
]}

Miyoshi, Hiroaki ^{[1
]}

Kiyasu, Junichi ^{[3
]}

Kamimura, Tomohiko ^{[4
]}

Eto, Tetsuya ^{[5
]}

Miyagishima, Takuto ^{[6
]}

Nagafuji, Koji ^{[7
]}

Seto, Masao ^{[1
]}

Teshima, Takanori ^{[2
]}

Ohshima, Koichi ^{[1
]}

机构：

[1] Kurume Univ, Sch Med, Dept Pathol, Kurume, Fukuoka, Japan

[2] Hokkaido Univ, Fac Med, Dept Hematol, Sapporo, Hokkaido, Japan

[3] Iizuka Hosp, Dept Hematol, Iizuka, Fukuoka, Japan

[4] Harasanshin Hosp, Dept Hematol, Fukuoka, Japan

[5] Hamanomachi Hosp, Dept Hematol, Fukuoka, Japan

[6] Kushiro Rosai Hosp, Dept Hematol, Kushiro, Hokkaido, Japan

[7] Kurume Univ, Sch Med, Dept Hematol, Kurume, Fukuoka, Japan

来源：

PLOS ONE | 2018年 / 13卷 / 04期

关键词：

CHROMOSOMAL INSTABILITY; DNA-PLOIDY; GENOMIC INSTABILITY; CANCER; HETEROGENEITY; SURVIVAL; POOR; EXPRESSION; PROGNOSIS; EVOLUTION;

D O I：

10.1371/journal.pone.0194525

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Polyploid chromosomes are those with more than two sets of homologous chromosomes. Polyploid chromosomal abnormalities are observed in various malignant tumors. The prognosis in such cases is generally poor. However, there are no studies examining the prognosis of diffuse large B-cell lymphoma (DLBCL) with polyploid chromosomal abnormalities. Therefore, we statistically compared the clinicopathological features between polyploid DLBCL and DLBCL without polyploid abnormalities. Herein, 51 polyploid DLBCL and 53 control (without polyploid chromosomal abnormalities) cases were examined. G-banding method was employed to define polyploidy by cytogenetic analysis. Subsequently, flow cytometric immunophenotyping and immunohistochemical staining were performed. Polyploid DLBCL was defined as DLBCL with either near-tetraploid or greater number of chromosomes, as detected by the G-band. In a survival analysis, a significantly worse overall survival (OS) was observed for polyploid DLBCL (p = 0.04; p = 0.02 in cases who received R-CHOP regimens). In a multivariate analysis of OS, polyploid chromosomal abnormalities were an independent prognostic factor. Our results suggest that polyploid chromosomal abnormalities detected through G-band may represent a new poor prognostic factor for DLBCL.

引用

页数：13

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