Type 17 T helper cells-origins, features and possible roles in rheumatic disease

被引：181
作者：
Annunziato, Francesco [1 ]
Cosmi, Lorenzo [1 ]
Liotta, Francesco [1 ]
Maggi, Enrico [1 ]
Romagnani, Sergio [1 ]
机构：
[1] Univ Florence, Dept Internal Med, Fac Med, I-50134 Florence, Italy
来源：
NATURE REVIEWS RHEUMATOLOGY | 2009年 / 5卷 / 06期
关键词：
COLLAGEN-INDUCED ARTHRITIS; GROWTH-FACTOR-BETA; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; INTERLEUKIN-12/23; MONOCLONAL-ANTIBODY; INFLAMMATORY-BOWEL-DISEASE; HYPER-IGE SYNDROME; HUMAN TH17 CELLS; ROR-GAMMA-T; TGF-BETA; DESTRUCTIVE ARTHRITIS;
D O I：
10.1038/nrrheum.2009.80
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Type 17 T helper (T(H)17) cells are a population of CD4(+) effector T cells that are distinct from T(H)1 and T(H)2 cells owing to their ability to produce interleukin (IL)-17. Although T(H)1 and T(H)2 cells are similar in mice and humans, T(H)17 cells differ in several ways. The differentiation of mouse T(H)17 cells requires transforming growth factor beta and IL-6, whereas human naive T cells can develop into T(H)17 cells in the presence of IL-1 beta and IL-23 alone, transforming growth factor beta having an indirect role in their development via the selective inhibition of T(H)1 cell expansion. in both mice and humans, a late developmental plasticity of T(H)17 cells towards the T(H)1 lineage has been shown. Mainly based on mouse gene knockout studies, T(H)17 lymphocytes have been found to have a pathogenic role in several autoimmune disorders; however, whether human autoimmune disorders, including rheumatoid arthritis (RA) and psoriasis, are prevalently T(H)1-mediated or T(H)17-mediated, is still unclear. research suggests that both T(H)1 and T(H)17 cells are involved in RA pathogenesis, raising the possibility that interventions that target both the IL-23-IL-17 (T(H)17) and the IL-12-interferon gamma(T(H)1) axes might be successful future therapeutic approaches for RA.
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页码：325 / 331
页数：7
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