Transcriptional control of macrophage polarisation in type 2 diabetes

被引：24
作者：
Drareni, Karima [1 ]
Gautier, Jean-Francois [1 ,2 ]
Venteclef, Nicolas [1 ]
Alzaid, Fawaz [1 ]
机构：
[1] Univ Paris Diderot, Univ Paris Descartes, Sorbonne Univ, USPC,Cordeliers Res Ctr,INSERM,Immun & Metab Diab, F-75006 Paris, France
[2] Univ Paris Diderot, Lariboisiere Hosp, AP HP, Diabetol Dept, Paris, France
来源：
SEMINARS IN IMMUNOPATHOLOGY | 2019年 / 41卷 / 04期
基金：
欧盟地平线“2020”;
关键词：
Inflammation; Diabetes; Macrophage; And transcription; ADIPOSE-TISSUE EXPANSION; NF-KAPPA-B; PPAR-GAMMA; INSULIN-RESISTANCE; GENE-EXPRESSION; INDUCED INFLAMMATION; LINKS INFLAMMATION; NUCLEAR RECEPTORS; STAT3; ACTIVATION; DENDRITIC CELL;
D O I：
10.1007/s00281-019-00748-1
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Type-2 diabetes (T2D) is considered today as an inflammatory disease. Inflammatory processes in T2D are orchestrated by macrophage activation in different organs. Macrophages undergo classical M1 pro-inflammatory or alternative M2 anti-inflammatory activation in response to tissue microenvironmental signals. These subsets of macrophages are characterised by their expression of cell surface markers, secreted cytokines and chemokines. Transcriptional regulation is central to the polarisation of macrophages, and several major pathways have been described as essential to promote the expression of specific genes, which dictate the functional polarisation of macrophages. In this review, we summarise the current knowledge of transcriptional control of macrophage polarisation and the role this plays in development of insulin resistance.
引用
收藏
页码：515 / 529
页数：15
相关论文
共 103 条
[1]   The transcriptional PPARβ/δ network in human macrophages defines a unique agonist-induced activation state [J].
Adhikary, Till ;
Wortmann, Annika ;
Schumann, Tim ;
Finkernagel, Florian ;
Lieber, Sonja ;
Roth, Katrin ;
Toth, Philipp M. ;
Diederich, Wibke E. ;
Nist, Andrea ;
Stiewe, Thorsten ;
Kleinesudeik, Lara ;
Reinartz, Silke ;
Mueller-Bruesselbach, Sabine ;
Mueller, Rolf .
NUCLEIC ACIDS RESEARCH, 2015, 43 (10) :5033-5051
[2]   IRF5 governs liver macrophage activation that promotes hepatic fibrosis in mice and humans [J].
Alzaid, Fawaz ;
Lagadec, Floriane ;
Albuquerque, Miguel ;
Ballaire, Raphaelle ;
Orliaguet, Lucie ;
Hainault, Isabelle ;
Blugeon, Corinne ;
Lemoine, Sophie ;
Lehuen, Agnses ;
Saliba, David G. ;
Udalova, Irina A. ;
Paradis, Valerie ;
Foufelle, Fabienne ;
Venteclef, Nicolas .
JCI INSIGHT, 2016, 1 (20)
[3]   A role for AP-1 in apoptosis: the case for and against [J].
Ameyar, M ;
Wisniewska, M ;
Weitzman, JB .
BIOCHIMIE, 2003, 85 (08) :747-752
[4]   Metainflammation in Diabetic Coronary Artery Disease: Emerging Role of Innate and Adaptive Immune Responses [J].
Aravindhan, Vivekanandhan ;
Madhumitha, Haridoss .
JOURNAL OF DIABETES RESEARCH, 2016, 2016
[5]   IKK-β links inflammation to obesity-induced insulin resistance [J].
Arkan, MC ;
Hevener, AL ;
Greten, FR ;
Maeda, S ;
Li, ZW ;
Long, JM ;
Wynshaw-Boris, A ;
Poli, G ;
Olefsky, J ;
Karin, M .
NATURE MEDICINE, 2005, 11 (02) :191-198
[6]   NF-κB, Inflammation, and Metabolic Disease [J].
Baker, Rebecca G. ;
Hayden, Matthew S. ;
Ghosh, Sankar .
CELL METABOLISM, 2011, 13 (01) :11-22
[7]   PPARγ activation primes human monocytes into alternative M2 macrophages with anti-inflammatory properties [J].
Bouhlel, M. Amine ;
Derudas, Bruno ;
Rigamonti, Elena ;
Dievart, Rebecca ;
Brozek, John ;
Haulon, Stephan ;
Zawadzki, Christophe ;
Jude, Brigitte ;
Torpier, Gerard ;
Marx, Nikolaus ;
Staels, Bart ;
Chinetti-Gbaguidi, Giulia .
CELL METABOLISM, 2007, 6 (02) :137-143
[8]   Adipose tissue macrophages: going off track during obesity [J].
Boutens, Lily ;
Stienstra, Rinke .
DIABETOLOGIA, 2016, 59 (05) :879-894
[9]   Hepatic protein tyrosine phosphatase receptor gamma links obesity-induced inflammation to insulin resistance [J].
Brenachot, Xavier ;
Ramadori, Giorgio ;
Ioris, Rafael M. ;
Veyrat-Durebex, Christelle ;
Altirriba, Jordi ;
Aras, Ebru ;
Ljubicic, Sanda ;
Kohno, Daisuke ;
Fabbiano, Salvatore ;
Clement, Sophie ;
Goossens, Nicolas ;
Trajkovski, Mirko ;
Harroch, Sheila ;
Negro, Francesco ;
Coppari, Roberto .
NATURE COMMUNICATIONS, 2017, 8
[10]   Evolutionary Origins of Toll-like Receptor Signaling [J].
Brennan, Joseph J. ;
Gilmore, Thomas D. .
MOLECULAR BIOLOGY AND EVOLUTION, 2018, 35 (07) :1576-1587
12345678910