A Proposal for a Coordinated Effort for the Determination of Brainwide Neuroanatomical Connectivity in Model Organisms at a Mesoscopic Scale

被引：203

作者：

Bohland, Jason W. ^{[1
]}

Wu, Caizhi ^{[1
]}

Barbas, Helen ^{[2
]}

Bokil, Hemant ^{[1
,4
]}

Bota, Mihail ^{[3
]}

Breiter, Hans C.

Cline, Hollis T. ^{[1
]}

Doyle, John C. ^{[5
]}

Freed, Peter J. ^{[6
]}

Greenspan, Ralph J. ^{[7
]}

Haber, Suzanne N. ^{[8
]}

Hawrylycz, Michael ^{[9
]}

Herrera, Daniel G. ^{[10
]}

Hilgetag, Claus C. ^{[11
]}

Huang, Z. Josh ^{[1
]}

Jones, Allan ^{[9
]}

Jones, Edward G. ^{[12
]}

Karten, Harvey J. ^{[13
]}

Kleinfeld, David ^{[14
]}

Kotter, Rolf ^{[15
]}

Lester, Henry A. ^{[16
]}

Lin, John M. ^{[1
]}

Mensh, Brett D. ^{[17
]}

Mikula, Shawn ^{[12
]}

Panksepp, Jaak ^{[18
]}

Price, Joseph L. ^{[19
]}

Safdieh, Joseph ^{[20
]}

Saper, Clifford B. ^{[21
]}

Schiff, Nicholas D. ^{[20
]}

Schmahmann, Jeremy D. ^{[22
]}

Stillman, Bruce W. ^{[1
]}

Svoboda, Karel ^{[23
]}

Swanson, Larry W. ^{[3
]}

Toga, Arthur W. ^{[24
]}

Van Essen, David C. ^{[19
]}

Watson, James D. ^{[1
]}

Mitra, Partha P. ^{[1
]}

机构：

[1] Cold Spring Harbor Lab, Cold Spring Harbor, NY 11724 USA

[2] Boston Univ, Dept Hlth Sci, Boston, MA 02215 USA

[3] Univ So Calif, Dept Biol Sci, Los Angeles, CA 90089 USA

[4] Massachusetts Gen Hosp, Dept Radiol, Charlestown, MA USA

[5] CALTECH, Dept Elect Engn, Pasadena, CA 91125 USA

[6] Columbia Univ, New York State Psychiat Inst, Med Ctr, New York, NY USA

[7] Inst Neurosci, San Diego, CA USA

[8] Univ Rochester, Med Ctr, Dept Physiol & Pharmacol, Rochester, NY 14642 USA

[9] Allen Inst Brain Sci, Seattle, WA USA

[10] Harvard Univ, Brigham & Womens Hosp, Dept Psychiat, Sch Med, Boston, MA 02115 USA

[11] Jacobs Univ Bremen, Sch Sci & Engn, Bremen, Germany

[12] Univ Calif Davis, Ctr Neurosci, Davis, CA 95616 USA

[13] Univ Calif San Diego, Sch Med, Dept Neurosci, La Jolla, CA 92093 USA

[14] Univ Calif San Diego, Dept Phys, La Jolla, CA 92093 USA

[15] Radboud Univ Nijmegen, Med Ctr, Donders Inst Brain Cognit & Behav, Dept Cognit Neurosci,NeuroPI, NL-6525 ED Nijmegen, Netherlands

[16] CALTECH, Dept Biol, Pasadena, CA 91125 USA

[17] Columbia Univ, Dept Psychiat, Med Ctr, New York, NY USA

[18] Washington State Univ, Coll Vet Med, Pullman, WA 99164 USA

[19] Washington Univ, Sch Med, Dept Anat & Neurobiol, St Louis, MO 63110 USA

[20] Weill Cornell Med Coll, Dept Neurol, New York, NY USA

[21] Beth Israel Deaconess Med Ctr, Dept Neurol, Boston, MA 02215 USA

[22] Massachusetts Gen Hosp, Dept Neurol, Boston, MA 02114 USA

[23] Howard Hughes Med Inst, Ashburn, VA USA

[24] Univ Calif Los Angeles, Sch Med, Dept Neurol, Lab NeuroImaging, Los Angeles, CA 90024 USA

来源：

PLOS COMPUTATIONAL BIOLOGY | 2009年 / 5卷 / 03期

关键词：

BIOTINYLATED DEXTRAN-AMINE; NERVOUS-SYSTEM; WHITE-MATTER; CORPUS-CALLOSUM; ORGANIZATION; ANTEROGRADE; NEUROINFORMATICS; IDENTIFICATION; NEUROSCIENCE; POPULATIONS;

D O I：

10.1371/journal.pcbi.1000334

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

In this era of complete genomes, our knowledge of neuroanatomical circuitry remains surprisingly sparse. Such knowledge is critical, however, for both basic and clinical research into brain function. Here we advocate for a concerted effort to fill this gap, through systematic, experimental mapping of neural circuits at a mesoscopic scale of resolution suitable for comprehensive, brainwide coverage, using injections of tracers or viral vectors. We detail the scientific and medical rationale and briefly review existing knowledge and experimental techniques. We define a set of desiderata, including brainwide coverage; validated and extensible experimental techniques suitable for standardization and automation; centralized, open-access data repository; compatibility with existing resources; and tractability with current informatics technology. We discuss a hypothetical but tractable plan for mouse, additional efforts for the macaque, and technique development for human. We estimate that the mouse connectivity project could be completed within five years with a comparatively modest budget.

引用

页数：9

共 72 条

[61] Coordinate-independent mapping of structural and functional data by objective relational transformation (ORT) [J].

Stephan, KE ;

Zilles, K ;

Kötter, R .

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 2000, 355 (1393) :37-54

[62] Advanced database methodology for the Collation of Connectivity data on the Macaque brain (CoCoMac) [J].

Stephan, KE ;

Kamper, L ;

Bozkurt, A ;

Burns, GAPC ;

Young, MP ;

Kötter, R .

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES, 2001, 356 (1412) :1159-1186

[63] Applied electric fields accelerate the diffusion rate and increase the diffusion distance of DiI in fixed tissue [J].

Swift, MJ ;

Crago, PE ;

Grill, WM .

JOURNAL OF NEUROSCIENCE METHODS, 2005, 141 (01) :155-163

[64] REGISTRATION REVISITED [J].

TOGA, AW ;

BANERJEE, PK .

JOURNAL OF NEUROSCIENCE METHODS, 1993, 48 (1-2) :1-13

[65]

Van Essen D.C., 2005, DATABASING BRAIN, P369

[66] Surface-based and probabilistic atlases of primate cerebral cortex [J].

Van Essen, David C. ;

Dierker, Donna L. .

NEURON, 2007, 56 (02) :209-225

[67] BIOTINYLATED DEXTRAN AMINE AS AN ANTEROGRADE TRACER FOR SINGLE-LABELING AND DOUBLE-LABELING STUDIES [J].

VEENMAN, CL ;

REINER, A ;

HONIG, MG .

JOURNAL OF NEUROSCIENCE METHODS, 1992, 41 (03) :239-254

[68] Recent techniques for tracing pathways in the central nervous system of developing and adult mammals [J].

Vercelli, A ;

Repici, M ;

Garbossa, D ;

Grimaldi, A .

BRAIN RESEARCH BULLETIN, 2000, 51 (01) :11-28

[69] GenePaint.org: an atlas of gene expression patterns in the mouse embryo [J].

Visel, A ;

Thaller, C ;

Eichele, G .

NUCLEIC ACIDS RESEARCH, 2004, 32 :D552-D556

[70]

WERNICKE K, 1977, WERNICKES WORKS APHA, P92

← 1 2 3 4 5 6 7 8 →