TRANSGLUTAMINASE REGULATION OF CELL FUNCTION

被引：333
作者：
Eckert, Richard L. [1 ]
Kaartinen, Mari T.
Nurminskaya, Maria
Belkin, Alexey M.
Colak, Gozde
Johnson, Gail V. W.
Mehta, Kapil
机构：
[1] Univ Maryland, Sch Med, Dept Biochem & Mol Biol, Baltimore, MD 21201 USA
来源：
PHYSIOLOGICAL REVIEWS | 2014年 / 94卷 / 02期
基金：
美国国家卫生研究院; 加拿大健康研究院;
关键词：
NF-KAPPA-B; VASCULAR SMOOTH-MUSCLE; TISSUE-TYPE TRANSGLUTAMINASE; GUANINE-NUCLEOTIDE-BINDING; FACTOR-XIII-A; CHONDROCYTE HYPERTROPHIC DIFFERENTIATION; GH-ALPHA/TISSUE TRANSGLUTAMINASE-2; EPITHELIAL-MESENCHYMAL TRANSITION; RECESSIVE LAMELLAR ICHTHYOSIS; HEPARAN-SULFATE PROTEOGLYCANS;
D O I：
10.1152/physrev.00019.2013
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
Transglutaminases (TGs) are multifunctional proteins having enzymatic and scaffolding functions that participate in regulation of cell fate in a wide range of cellular systems and are implicated to have roles in development of disease. This review highlights the mechanism of action of these proteins with respect to their structure, impact on cell differentiation and survival, role in cancer development and progression, and function in signal transduction. We also discuss the mechanisms whereby TG level is controlled and how TGs control downstream targets. The studies described herein begin to clarify the physiological roles of TGs in both normal biology and disease states.
引用
收藏
页码：383 / 417
页数：35
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