A genome-wide search for susceptibility genes linked to alcohol dependence

被引：0
|
作者：
Peterson, LE
Barnholtz, JS
Page, GP
King, TM
de Andrade, M
Amos, CI
机构：
[1] Baylor Coll Med, Dept Med, Houston, TX 77030 USA
[2] Univ Texas, Sch Publ Hlth, Dept Biometry, Houston, TX USA
[3] Univ Texas, MD Anderson Canc Ctr, Dept Epidemiol, Houston, TX 77030 USA
来源：
GENETIC EPIDEMIOLOGY | 1999年 / 17卷
关键词：
alcoholism; genetic linkage analysis;
D O I：
暂无
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
We performed two-point linkage analysis during a genome-wide search for susceptibility genes that predispose to alcohol dependence with the Collaborative Study on the Genetics on Alcoholism (COGA) data made available for the Genetic Analysis Workshop 11 (GAW11). For chromosomes 1 and 4 our findings supported results reported by Reich et al. [1998] based on the same data. We found similarity between our findings in regions on chromosomes 8 and 10 and reported results for schizophrenia linkage studies. Differences between our results with COGA data and those obtained by Reich et al. [1998] are due to our use of a lod score method versus their use of the affected relative pair (sib pair) method. (C) 1999 Wiley-Liss, Inc.
引用
收藏
页码：S295 / S300
页数：6
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