PDMS Microchannel Regenerative Peripheral Nerve Interface

被引：0
|
作者：
Musick, Katherine M. [1 ]
Chew, Daniel J. [2 ]
Fawcett, James W. [2 ]
Lacour, Stephanie P. [1 ]
机构：
[1] EPFL STI IMT IBI LSBI, Ctr Neuroprosthet, CH-1015 Lausanne, Switzerland
[2] Univ Cambridge, Cambridge Ctr Brain Repair, Cambridge CB2 0PY, England
来源：
2013 6TH INTERNATIONAL IEEE/EMBS CONFERENCE ON NEURAL ENGINEERING (NER) | 2013年
关键词：
D O I：
暂无
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
We have fabricated a soft silicone structure to support the regeneration of a sciatic nerve. The device consists of 70 parallel (120 x 110 mu m(2)) channels through which axons extend and then reconnect to the muscles on the other side of the device. Through histology and electrophysiology, we show that axons grow through the device and functionality of the muscle control is restored. Nerve functionality as demonstrated with stimulated electromyography (EMG) recordings is still intact at 9 months after implantation. Future work on this device will include electrodes for recording and stimulating the regenerating nerve.
引用
收藏
页码：649 / 652
页数：4
相关论文
共 50 条
  • [1] Regenerative Microchannel Electrode Array for Peripheral Nerve Interfacing
    Srinivasan, Akhil
    Guo, Liang
    Bellamkonda, Ravi V.
    2011 5TH INTERNATIONAL IEEE/EMBS CONFERENCE ON NEURAL ENGINEERING (NER), 2011, : 253 - 256
  • [2] Handcrafted multilayer PDMS microchannel scaffolds for peripheral nerve regeneration
    Ridwan Hossain
    Bongkyun Kim
    Rachel Pankratz
    Ali Ajam
    Sungreol Park
    Sibani L. Biswal
    Yoonsu Choi
    Biomedical Microdevices, 2015, 17
  • [3] Handcrafted multilayer PDMS microchannel scaffolds for peripheral nerve regeneration
    Hossain, Ridwan
    Kim, Bongkyun
    Pankratz, Rachel
    Ajam, Ali
    Park, Sungreol
    Biswal, Sibani L.
    Choi, Yoonsu
    BIOMEDICAL MICRODEVICES, 2015, 17 (06)
  • [4] A PDMS Microchannel Scaffold with Microtube Electrodes for Peripheral Nerve Interfacing
    Kim, Bongkyun
    Ibarra, Everardo
    Reyes, Alejandro
    Garza, Bernardo
    Luna, Rosalio
    Choi, Yoonsu
    IECON 2014 - 40TH ANNUAL CONFERENCE OF THE IEEE INDUSTRIAL ELECTRONICS SOCIETY, 2014, : 2302 - 2307
  • [5] Electrode Characterization for Use in a Regenerative Peripheral Nerve Interface
    Larson, John V.
    Goretski, Stephanie A.
    Cockrum, Joshua W.
    Urbanchek, Melanie G.
    Cederna, Paul S.
    Langhals, Nicholas B.
    2013 6TH INTERNATIONAL IEEE/EMBS CONFERENCE ON NEURAL ENGINEERING (NER), 2013, : 629 - 632
  • [6] Regenerative Peripheral Nerve Interface for Management of Postamputation Neuroma
    Kubiak, Carrie A.
    Kemp, Stephen W. P.
    Cederna, Paul S.
    JAMA SURGERY, 2018, 153 (07) : 681 - 682
  • [7] In vivo characterization of regenerative peripheral nerve interface function
    Department of Mechanical Engineering, University of Michigan, Ann Arbor
    MI, United States
    不详
    J. Neural Eng., 1741, 2
  • [8] In vivo characterization of regenerative peripheral nerve interface function
    Ursu, Daniel C.
    Urbanchek, Melanie G.
    Nedic, Andrej
    Cederna, Paul S.
    Gillespie, R. Brent
    JOURNAL OF NEURAL ENGINEERING, 2016, 13 (02)
  • [9] The Muscle Cuff Regenerative Peripheral Nerve Interface for the Amplification of Intact Peripheral Nerve Signals
    Svientek, Shelby R.
    Wisely, Justin P.
    Dehdashtian, Amir
    Bratley, Jarred, V
    Cederna, Paul S.
    Kemp, Stephen W. P.
    JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, 2022, (179):
  • [10] Regenerative peripheral nerve interface prevents neuroma formation after peripheral nerve transection
    Wang, Zheng
    Yi, Xin-Zeyu
    Yu, Ai-Xi
    NEURAL REGENERATION RESEARCH, 2023, 18 (04) : 814 - 818
12345