β-tting on p63 as a Metastatic Suppressor

被引：7
作者：
Clohessy, John G. [1 ,2 ]
Pandolfi, Pier Paolo [1 ,2 ]
机构：
[1] Harvard Univ, Sch Med, Beth Israel Deaconess Canc Ctr, Canc Gene Program, Boston, MA 02215 USA
[2] Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Dept Pathol & Med, Boston, MA 02215 USA
来源：
CELL | 2009年 / 137卷 / 01期
关键词：
TGF-BETA; MUTANT;
D O I：
10.1016/j.cell.2009.03.028
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Although much is known about the genes that promote metastasis, few suppressors of metastasis have been found. Adorno et al. (2009) now identify p63 as a potent suppressor of metastasis and uncover an intricate mechanism for the inactivation of metastasis in cancer cells in response to transforming growth factor beta.
引用
收藏
页码：28 / 31
页数：4
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  • [1] Integration of TGF-β and Ras/MAPK signaling through p53 phosphorylation
    Cordenonsi, Michelangelo
    Montagner, Marco
    Adorno, Maddalena
    Zacchigna, Luca
    Martello, Graziano
    Mamidi, Anant
    Soligo, Sandra
    Dupont, Sirio
    Piccolo, Stefano
    [J]. SCIENCE, 2007, 315 (5813) : 840 - 843
  • [2] Cyclin G2 is a centrosome-associated nucleocytoplasmic shuttling protein that influences microtubule stability and induces a p53-dependent cell cycle arrest
    Don, Aruni S. Arachchige
    Dallapiazza, Robert F.
    Bennin, David A.
    Brake, Tiffany
    Cowan, Colleen E.
    Horne, Mary C.
    [J]. EXPERIMENTAL CELL RESEARCH, 2006, 312 (20) : 4181 - 4204
  • [3] Concordance among gene-expression-based predictors for breast cancer
    Fan, Cheng
    Oh, Daniel S.
    Wessels, Lodewyk
    Weigelt, Britta
    Nuyten, Dimitry S. A.
    Nobel, Andrew B.
    van't Veer, Laura J.
    Perou, Charles M.
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2006, 355 (06) : 560 - 569
  • [4] Tumor predisposition in mice mutant for p63 and p73:: Evidence for broader tumor suppressor functions for the p53 family
    Flores, ER
    Sengupta, S
    Miller, JB
    Newman, JJ
    Bronson, R
    Crowley, D
    Yang, A
    McKeon, F
    Jacks, T
    [J]. CANCER CELL, 2005, 7 (04) : 363 - 373
  • [5] TGFβ primes breast tumors for lung metastasis seeding through angiopoietin-like 4
    Padua, David
    Zhang, Xiang H. -F.
    Wang, Qiongqing
    Nadal, Cristina
    Gerald, William L.
    Gomis, Roger R.
    Massague, Joan
    [J]. CELL, 2008, 133 (01) : 66 - 77
  • [6] Roles of TGFβ in metastasis
    Padua, David
    Massague, Joan
    [J]. CELL RESEARCH, 2009, 19 (01) : 89 - 102
  • [7] Disturbed Clockwork Resetting in Sharp-1 and Sharp-2 Single and Double Mutant Mice
    Rossner, Moritz J.
    Oster, Henrik
    Wichert, Sven P.
    Reinecke, Lisa
    Wehr, Michael C.
    Reinecke, Johannes
    Eichele, Gregor
    Taneja, Reshma
    Nave, Klaus-Armin
    [J]. PLOS ONE, 2008, 3 (07):
  • [8] p63 is essential for the proliferative potential of stem cells in stratified epithelia
    Senoo, Makoto
    Pinto, Filipa
    Crum, Christopher P.
    McKeon, Frank
    [J]. CELL, 2007, 129 (03) : 523 - 536
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