One-pot synthesis of benzo[b]furan and indole inhibitors of tubulin polymerization

被引：268

作者：

Flynn, BL ^{[1
]}

Hamel, E

Jung, MK

机构：

[1] Australian Natl Univ, Dept Chem, Canberra, ACT 0200, Australia

[2] NCI, Screening Technol Branch, Dev Therapeut Program, Div Canc Treatment & Diag,NIH, Frederick, MD 21702 USA

[3] NCI, Sci Applicat Int Corp, NIH, Frederick, MD 21702 USA

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 2002年 / 45卷 / 12期

关键词：

D O I：

10.1021/jm020077t

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Benzo[b]furan and indole analogues of some recently identified benzo[b]thiophene inhibitors of tubulin polymerization have been prepared, and their biological activity has been assessed. Several very potent analogues were identified.

引用

页码：2670 / 2673

页数：4

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