Study of a controlled release polymeric system based on Pluronic P123: Spectroscopic characterization and theoretical model approach

被引：16

作者：

Arroyo, E. ^{[1
]}

Luque, P. A. ^{[2
]}

Cosio, M. ^{[2
]}

Soto, C. ^{[2
]}

Villarreal, R. ^{[2
]}

Nava, O. ^{[2
]}

Olivas, A. ^{[3
]}

机构：

[1] UNAM, PCeIM, Ctr Nanociencias & Nanotecnol, Ensenada 22860, BC, Mexico

[2] Univ Autonoma Baja California, FIAD, Ensenada 22860, BC, Mexico

[3] UNAM, Ctr Nanociencias & Nanotecnol, Ensenada 22860, BC, Mexico

来源：

JOURNAL OF MOLECULAR STRUCTURE | 2017年 / 1138卷

关键词：

Drug delivery; Indomethacin; Poly-ethylene-glycol (PEG); Poly-N-vinyl pyrrolidone (PVP); Pluronic P123; BLOCK-COPOLYMERS; DRUG-DELIVERY; MICELLES; INDOMETHACIN; IMIQUIMOD;

D O I：

10.1016/j.molstruc.2017.03.018

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

This work reports the profiles of drug release systems based on different polymers for the potential use as a skin anti-inflammatory. The materials used for the encapsulation of indomethacin were Pluronic P123 with various combinations of poly-ethylene-glycol and poly-N-vinyl pyrrolidone. These systems were characterized via Fourier transform infrared spectrometry and high resolution transmission electron microscopy. The morphology showed the treated polymers as spheres. Drug loadings were carried out via the absorption in solution method; this load was of a 1:10 wt ratio indomethacin to polymers. Drug release tests were performed via the dialysis method pH 7.2 phosphate buffered saline at 32 degrees C. The drug concentration was determined via UV-Vis spectroscopy, and additionally, a theoretical model was developed based on diffusion equations to describe the phenomenon. Comparison between the experimental results and theory was close to 5%. (C) 2017 Elsevier B.V. All rights reserved.

引用

页码：172 / 176

页数：5

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