Melanogenesis inhibitors from the rhizomes of Alpinia officinarum in B16 melanoma cells

被引：88

作者：

Matsuda, Hisashi ^{[1
]}

Nakashima, Souichi ^{[1
]}

Oda, Yoshimi ^{[1
]}

Nakamura, Seikou ^{[1
]}

Yoshikawa, Masayuki ^{[1
]}

机构：

[1] Kyoto Pharmaceut Univ, Yamashina Ku, Kyoto 6078412, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2009年 / 17卷 / 16期

关键词：

Alpinia officinarum; Melanogenesis inhibitor; Diarylheptanoid; Flavonoid; Tyrosinase; Tyrosinase-related protein; CULTURED HUMAN MELANOCYTES; STRUCTURAL REQUIREMENTS; ANTIOXIDATIVE COMPOUNDS; STIMULATING HORMONE; MUSHROOM TYROSINASE; PANCREATIC LIPASE; DIARYLHEPTANOIDS; HANCE; BIOSYNTHESIS; EXPRESSION;

D O I：

10.1016/j.bmc.2009.06.057

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The 80% aqueous acetone extract from the rhizomes of Alpinia officinarum, a Chinese medicinal herb, were found to inhibit melanogenesis in theophylline-stimulated murine B16 melanoma 4A5 cells. Among the constituents isolated, four diarylheptanoids [5-hydroxy-1,7-diphenyl-3-heptanone, 7-(4 ''-hydroxy-3 ''-methoxyphenyl)- 1-phenylhept-4-en-3-one, 5-hydroxy-7-(4 ''-hydroxy-300-methoxyphenyl)-1-phenyl-3-heptanone, and 3,5-dihydroxy-1,7-diphenylheptane] and two flavonol constituents (kaempferide and galangin) inhibited melanogenesis with IC50 values of 10-48 mu M, and several structural requirements of the active constituents for the inhibition were clarified. In addition, 7-(4 ''-hydroxy-3 ''-methoxyphenyl)- 1-phenylhept-4-en-3-one, kaempferide, and galangin inhibited mRNA expression of tyrosinase and tyrosinase-related proteins-1 and -2, and the protein level of a microphthalmia-associated transcription factor. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：6048 / 6053

页数：6

共 48 条

[1] Melanogenesis inhibitory and free radical scavenging activities of diarylheptanoids and other phenolic compounds from the bark of Acer nikoense [J].